ReviewJournal of developmental biology2021
The Skull's Girder: A Brief Review of the Cranial Base.
Review in Journal of developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Association between single-nucleotide polymorphisms in endochondral development-related genes and 3D phenotypic variation of the cranial base.Head & face medicine · 2026Article
- Article
- A Clinical Prediction Model for Genetic Risk in Children with GDD/ID: A Retrospective Study.Pediatric reports · 2025Article
- Reliability and reproducibility of CBCT assessment of craniomaxillary changes before and after treatment for Class III growing patients - a cautious or critical approach.BMC pediatrics · 2025Article
- RUNX2 is essential for maintaining synchondrosis chondrocytes and cranial base growth.Bone research · 2025Article
- Deficiencies in corin and atrial natriuretic peptide-mediated signaling impair endochondral ossification in bone development.Communications biology · 2024Article
- Assessing the morphology and bone mineral density of the immature pars lateralis as an indicator of age.International journal of legal medicine · 2024Article
- Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model.Nature genetics · 2023Article
- Augmentation of bone morphogenetic protein signaling in cranial neural crest cells in mice deforms skull base due to premature fusion of intersphenoidal synchondrosis.Genesis (New York, N.Y. : 2000) · 2023Article
- Cranial Base Synchondrosis Lacks PTHrP-Expressing Column-Forming Chondrocytes.International journal of molecular sciences · 2022Article
- Cranial Base Synchondrosis: Chondrocytes at the Hub.International journal of molecular sciences · 2022Review
- Advances in Understanding the Pathogenesis of Craniofacial Birth Defects.Journal of developmental biology · 2022Article
- Micro-computed tomography assessment of bone structure in aging mice.Scientific reports · 2022Article
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The cranial base is a multifunctional bony platform within the core of the cranium, spanning rostral to caudal ends. This structure provides support for the brain and skull vault above, serves as a link between the head and the vertebral column below, and seamlessly integrates with the facial skeleton at its rostral end. Unique from the majority of the cranial skeleton, the cranial base develops from a cartilage intermediate-the chondrocranium-through the process of endochondral ossification. Owing to the intimate association of the cranial base with nearly all aspects of the head, congenital birth defects impacting these structures often coincide with anomalies of the cranial base. Despite this critical importance, studies investigating the genetic control of cranial base development and associated disorders lags in comparison to other craniofacial structures. Here, we highlight and review developmental and genetic aspects of the cranial base, including its transition from cartilage to bone, dual embryological origins, and vignettes of transcription factors controlling its formation.
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Registered trials
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