Evidence map›Paper›PMID 33498617›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Muscle Ultrasound Shear Wave Elastography as a Non-Invasive Biomarker in Myotonia.

Cornelius Kronlage, Alexander Grimm, Alyssa Romano, Jan-Hendrik Stahl, Pascal Martin, Natalie Winter, Justus Marquetand

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06701318 (Ultrasound Shear Wave Elastography for Assessing Muscle Stiffness in Parkinson's Disease Patients), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06701318 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Ultrasound Shear Wave Elastography for Assessing Muscle Stiffness in Parkinson's Disease Patients

TypeobservationalSponsorAssiut UniversityRan2025 to 2026Enrolled68ConditionsParkinson DiseaseArmsUltrasound shear wave elastography
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cornelius KronlageDepartment of Neurology and Epileptology, University Hospital Tübingen and Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.
Alexander GrimmDepartment of Neurology and Epileptology, University Hospital Tübingen and Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.
Alyssa RomanoDepartment of Neurology and Epileptology, University Hospital Tübingen and Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.
Jan-Hendrik StahlDepartment of Neurology and Epileptology, University Hospital Tübingen and Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.
Pascal MartinDepartment of Neurology and Epileptology, University Hospital Tübingen and Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.
Natalie WinterDepartment of Neurology and Epileptology, University Hospital Tübingen and Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.
Justus MarquetandDepartment of Neurology and Epileptology, University Hospital Tübingen and Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.
Hertie Institute for Clinical Brain Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myotonia, i.e., delayed muscle relaxation in certain hereditary muscle disorders, can be assessed quantitatively using different techniques ranging from force measurements to electrodiagnostics. Ultrasound shear wave elastography (SWE) has been proposed as a novel tool in biomechanics and neuromuscular medicine for the non-invasive estimation of muscle elasticity and, indirectly, muscle force. The aim of this study is to provide 'proof-of-principle' that SWE allows a quantitative measurement of the duration of delayed muscle relaxation in myotonia in a simple clinical setting. In six myotonic muscle disorder patients and six healthy volunteers, shear wave velocities (SWV) parallel to the fiber orientation in the flexor digitorum superficialis muscle in the forearm were recorded with a temporal resolution of one per second during fist-clenching and subsequent relaxation; the relaxation time to 10% of normalized shear wave velocity (RT

Indexed as

musclemyotoniashear-wave elastographyultrasound elastography

Identifiers

PMID33498617
PMCPMC7911703
OpenAlexW3121905474

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.