ReviewBiomimetics (Basel, Switzerland)2021
Mesoporous Bioactive Glasses Cytocompatibility Assessment: A Review of In Vitro Studies.
Review in Biomimetics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Bioglasses as Local Drug Delivery System of Ketoprofen for Regenerative Medicine.Materials (Basel, Switzerland) · 2026Article
- Mesoporous Bioactive Glass: Preparation, Characterisation, and Emerging Applications in Regenerative Medicine and Dentistry.International dental journal · 2026Review
- Evaluating cell viability assessment techniques: a comparative study of flow cytometry and fluorescence microscopy in response to bioactive glass exposure.Biomedical engineering online · 2025Article
- The Assessment of Bioactivity and Biological Responsiveness in Bioactive Glasses and Ceramics: A Review of Available Techniques.Materials (Basel, Switzerland) · 2025Review
- Greener Synthesis of Eco-Friendly Biodegradable Mesoporous Bioactive Glasses with and Without Thermal Treatment and Its Effects on Drug Delivery and In Vitro Bioactivity.International journal of molecular sciences · 2025Article
- Impact of composition and surfactant-templating on mesoporous bioactive glasses structural evolution, bioactivity, and drug delivery property.Journal of biomaterials applications · 2025Article
- Balanced enhancement of antibacterial activity and biocompatibility in chitosan-vancomycin 3D-printed scaffolds through mesoporous bioactive glass addition.Journal of drug delivery science and technology · 2025Article
- Engineering mesoporous bioactive glasses for emerging stimuli-responsive drug delivery and theranostic applications.Bioactive materials · 2024Review
- Sustained Release of Voriconazole Using 3D-Crosslinked Hydrogel Rings and Rods for Use in Corneal Drug Delivery.Gels (Basel, Switzerland) · 2023Article
- Prosthetic Joint Infections: Biofilm Formation, Management, and the Potential of Mesoporous Bioactive Glass as a New Treatment Option.Pharmaceutics · 2023Review
- Investigation of Surface Layers on Biological and Synthetic Hydroxyapatites Based on Bone Mineralization Process.Biomimetics (Basel, Switzerland) · 2023Review
- Amelogenin-Derived Peptide (ADP-5) Hydrogel for Periodontal Regeneration: An In Vitro Study on Periodontal Cells Cytocompatibility, Remineralization and Inflammatory Profile.Journal of functional biomaterials · 2023Article
- Sol-gel synthesis of lithium doped mesoporous bioactive glass nanoparticles and tricalcium silicate for restorative dentistry: Comparative investigation of physico-chemical structure, antibacterial susceptibility and biocompatibility.Frontiers in bioengineering and biotechnology · 2023Article
- Bone Regeneration and Oxidative Stress: An Updated Overview.Antioxidants (Basel, Switzerland) · 2022Review
- Mesoporous Bioglasses Enriched with Bioactive Agents for Bone Repair, with a Special Highlight of María Vallet-Regí's Contribution.Pharmaceutics · 2022Review
- Comparative Evaluation of Corneal Storage Medias Used as Tooth Avulsion Medias in Maintaining the Viability of Periodontal Ligament Cells Using the Cell Counting Kit-8 Assay.Clinical, cosmetic and investigational dentistry · 2022Article
- Mesoporous bioactive glasses for regenerative medicine.Materials today. Bio · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thanks to their high porosity and surface area, mesoporous bioactive glasses (MBGs) have gained significant interest in the field of medical applications, in particular, with regards to enhanced bioactive properties which facilitate bone regeneration. The aim of this article is to review the state of the art regarding the biocompatibility evaluation of MBGs and provide a discussion of the various approaches taken. The research was performed using PubMed database and covered articles published in the last five years. From a total of 91 articles, 63 were selected after analyzing them according to our inclusion and exclusion criteria. In vitro methodologies and techniques used for biocompatibility assessment were investigated. Among the biocompatibility assessment techniques, scanning electron microscopy (SEM) has been widely used to study cell morphology and adhesion. Viability and proliferation were assessed using different assays including cell counting and/or cell metabolic activity measurement. Finally, cell differentiation tests relied on the alkaline phosphatase assay; however, these were often complemented by specific bimolecular tests according to the exact application of the mesoporous bioactive glass. The standardization and validation of all tests performed for MBG cytocompatibility is a key aspect and crucial point and should be considered in order to avoid inconsistencies, bias between studies, and unnecessary consumption of time. Therefore, introducing standard tests would serve an important role in the future assessment and development of MBG materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.