Evidence map›Paper›PMID 33498505›Full record

ArticleCancers2021

Circulating Exosomal Integrin β3 Is Associated with Intracranial Failure and Survival in Lung Cancer Patients Receiving Cranial Irradiation for Brain Metastases: A Prospective Observational Study.

Guann-Yiing Chen, Jason Chia-Hsien Cheng, Ya-Fang Chen, James Chih-Hsin Yang, Feng-Ming Hsu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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  18. The therapeutic potential of exosomes in lung cancer.Cellular oncology (Dordrecht, Netherlands) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Guann-Yiing ChenDivision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei 100, Taiwan.
Jason Chia-Hsien ChengDivision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei 100, Taiwan.
Ya-Fang ChenDepartment of Medical Imaging, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu 300, Taiwan.
James Chih-Hsin YangGraduate Institute of Oncology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Feng-Ming HsuDivision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei 100, Taiwan.ORCID 0000-0001-9943-6039
National Taiwan University · TWNational Taiwan University Hospital · TW

Funding

Ministry of Science and Technology, Taiwan 107-2314-B-002 -098
6 · The paper itself

Abstract

Brain metastasis (BM) is a major problem in patients with cancer. Exosomes or extracellular vesicles (EV) and integrins contribute to the development of BM, and exosomal integrins have been shown to determine organotropic metastasis. We hypothesized that circulating EV integrins are able to influence the failure patterns and outcomes in patients treated for BM. We prospectively enrolled 75 lung cancer patients with BM who received whole brain radiotherapy (WBRT). We isolated and quantified their circulating EV integrins, and analyzed the association of EV integrins with clinical factors, survival, and intracranial/extracranial failure. Circulating EV integrin levels were independent of age, sex, histology, number of BM, or graded prognostic assessment score. Age, histology, and graded prognostic assessment score correlated with survival. Patients with higher levels of circulating EV integrin β3 had worse overall survival (hazard ratio: 1.15 per 1 ng/mL increase;

Indexed as

biomarkerbrain metastasiscirculating exosomesexosomal integrinsextracellular vesicleswhole brain radiotherapy

Identifiers

PMID33498505
PMCPMC7864205
OpenAlexW3121744889

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.