Evidence map›Paper›PMID 33498434›Full record

ArticleCancers2021

Neuroendocrine Neoplasms: Identification of Novel Metabolic Circuits of Potential Diagnostic Utility.

Beatriz Jiménez, Mei Ran Abellona U, Panagiotis Drymousis, Michael Kyriakides, Ashley K Clift, Daniel S K Liu, Eleanor Rees, Elaine Holmes, Jeremy K Nicholson, James M Kinross and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Metabolic changes in neuroendocrine neoplasms.Cellular and molecular life sciences : CMLS · 2025
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Beatriz JiménezDepartment of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.ORCID 0000-0003-4593-6075
Mei Ran Abellona UDepartment of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.ORCID 0000-0002-2147-5190
Panagiotis DrymousisDepartment of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Michael KyriakidesDepartment of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Ashley K CliftDepartment of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Daniel S K LiuDepartment of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.ORCID 0000-0002-4153-504X
Eleanor ReesDepartment of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Elaine HolmesDepartment of Metabolism, Nutrition and Reproduction, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Jeremy K NicholsonThe Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth 6150, Australia.
James M KinrossDepartment of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Andrea FrillingDepartment of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.ORCID 0000-0001-6130-2035
Imperial College London · GBMurdoch University · AU

Funding

Commission of the European Committees/FP7 FP7-MC-IEF 300586Dr. Heinz-Horst Deichmann-Stiftung P31294NIHR Imperial Biomedical Research Centre P47850UKINETS P52805
6 · The paper itself

Abstract

The incidence of neuroendocrine neoplasms (NEN) is increasing, but established biomarkers have poor diagnostic and prognostic accuracy. Here, we aim to define the systemic metabolic consequences of NEN and to establish the diagnostic utility of proton nuclear magnetic resonance spectroscopy (

Indexed as

biomarkersmetabolic profilingmetabonomicsneuroendocrine neoplasmsneuroendocrine tumoursnuclear magnetic resonanceprecision medicine

Identifiers

PMID33498434
PMCPMC7864182
OpenAlexW3125241386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.