Evidence map›Paper›PMID 33498298›Full record

ArticleInternational journal of molecular sciences2021

A Mitochondrial Polymorphism Alters Immune Cell Metabolism and Protects Mice from Skin Inflammation.

Paul Schilf, Axel Künstner, Michael Olbrich, Silvio Waschina, Beate Fuchs, Christina E Galuska, Anne Braun, Kerstin Neuschütz, Malte Seutter, Katja Bieber and 10 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Meeting Report on "10th Anniversary Symposium on Inflammatory Skin Disease".JID innovations : skin science from molecules to population health · 2025
    Article
  3. Exogenous expression of ATP8, a mitochondrial encoded protein, from the nucleusMolecular therapy. Methods & clinical development · 2024
    Article
  4. Article
  5. Mitochondrial heterogeneity in diseases.Signal transduction and targeted therapy · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Current Knowledge in Skin Metabolomics: Updates from Literature Review.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Paul SchilfLuebeck Institute of Experimental Dermatology, University of Luebeck, 23562 Luebeck, Germany.
Axel KünstnerLuebeck Institute of Experimental Dermatology, University of Luebeck, 23562 Luebeck, Germany.ORCID 0000-0003-0692-2105
Michael OlbrichLuebeck Institute of Experimental Dermatology, University of Luebeck, 23562 Luebeck, Germany.
Silvio WaschinaInstitute of Human Nutrition and Food Science, Christian-Albrechts-University of Kiel, 24098 Kiel, Germany.ORCID 0000-0002-6290-3593
Beate FuchsLeibniz-Institute for Farm Animal Biology (FBN), Core Facility Metabolomics, 18196 Dummerstorf, Germany.
Christina E GaluskaLeibniz-Institute for Farm Animal Biology (FBN), Core Facility Metabolomics, 18196 Dummerstorf, Germany.
Anne BraunDepartment of Dermatology, University of Luebeck, 23562 Luebeck, Germany.
Kerstin NeuschützLuebeck Institute of Experimental Dermatology, University of Luebeck, 23562 Luebeck, Germany.ORCID 0000-0002-9554-1509
Malte SeutterDepartment of Dermatology, University of Luebeck, 23562 Luebeck, Germany.
Katja BieberLuebeck Institute of Experimental Dermatology, University of Luebeck, 23562 Luebeck, Germany.ORCID 0000-0002-3855-6683
Lars HellbergDepartment of Infectious Diseases and Microbiology, University of Luebeck, 23562 Luebeck, Germany.
Christian SinaInstitute of Nutritional Medicine, University of Luebeck, 23562 Luebeck, Germany.
Tamás LaskayDepartment of Infectious Diseases and Microbiology, University of Luebeck, 23562 Luebeck, Germany.
Jan RuppDepartment of Infectious Diseases and Microbiology, University of Luebeck, 23562 Luebeck, Germany.
Ralf J LudwigLuebeck Institute of Experimental Dermatology, University of Luebeck, 23562 Luebeck, Germany.
Detlef ZillikensDepartment of Dermatology, University of Luebeck, 23562 Luebeck, Germany.
Hauke BuschLuebeck Institute of Experimental Dermatology, University of Luebeck, 23562 Luebeck, Germany.ORCID 0000-0003-4763-4521
Christian D SadikDepartment of Dermatology, University of Luebeck, 23562 Luebeck, Germany.ORCID 0000-0001-6701-048X
Misa HiroseLuebeck Institute of Experimental Dermatology, University of Luebeck, 23562 Luebeck, Germany.
Saleh M IbrahimLuebeck Institute of Experimental Dermatology, University of Luebeck, 23562 Luebeck, Germany.
University of Lübeck · DEInstitute for Integrative and Experimental Genomics · DEResearch Institute for Farm Animal Biology (FBN) · DEChristian-Albrechts-Universität zu Kiel · DEUniversity of Sharjah · AE

Funding

Bundesministerium für Bildung und Forschung 0315892BDeutsche Forschungsgemeinschaft CRC1182Deutsche Forschungsgemeinschaft CRU303Deutsche Forschungsgemeinschaft EXC306
6 · The paper itself

Abstract

Several genetic variants in the mitochondrial genome (mtDNA), including ancient polymorphisms, are associated with chronic inflammatory conditions, but investigating the functional consequences of such mtDNA polymorphisms in humans is challenging due to the influence of many other polymorphisms in both mtDNA and the nuclear genome (nDNA). Here, using the conplastic mouse strain B6-mt

Indexed as

Polymorphism, Single NucleotideAnimalsCells, CulturedCytokinesDNA, MitochondrialEpidermolysis Bullosa AcquisitaLymphocytesMiceMice, Inbred C57BLMitochondria, LiverMitochondrial Proton-Translocating ATPasesCytokinesDNA, MitochondrialMitochondrial Proton-Translocating ATPasesmt-Atp8 protein, mouseATP8autoimmune diseasecomplex Vconplastic miceimmunometabolismmetabolomicsmitochondriamt-Atp8mtDNA polymorphismspropionateshort chain fatty acidsskin inflammation

Identifiers

PMID33498298
PMCPMC7863969
OpenAlexW3125488465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.