Evidence map›Paper›PMID 33498229›Full record

ReviewPharmaceuticals (Basel, Switzerland)2021

Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review.

Nuha Al-Harbi, Hiba Mohammed, Yas Al-Hadeethi, Ahmed Samir Bakry, Ahmad Umar, Mahmoud Ali Hussein, Mona Aly Abbassy, Karthik Gurunath Vaidya, Ghada Al Berakdar, Elmoiz Merghni Mkawi and 1 more

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
  2. NiRSC advances · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Exploring New Horizons in Wound Healing: A Comprehensive Analysis.Recent advances in inflammation & allergy drug discovery · 2026
    Review
  9. SrO-Containing Bioactive Glasses in the SiOACS biomaterials science & engineering · 2025
    Review
  10. Review
  11. Review
  12. Innovative Smart Materials in Restorative Dentistry.Journal of functional biomaterials · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nuha Al-HarbiDepartment of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Hiba MohammedFondazione Novara Sviluppo, 28100 Novara, Italy.
Yas Al-HadeethiDepartment of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ahmed Samir BakryOperative Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ahmad UmarDepartment of Chemistry, Faculty of Science and Arts, Najran University, P.O. Box 1988, Najran 11001, Saudi Arabia.
Mahmoud Ali HusseinDepartment of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-5128-5136
Mona Aly AbbassyDepartment of Orthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Karthik Gurunath VaidyaManipal Institute of Regenerative Medicine (MIRM), Manipal Academy of Higher Education (MAHE), Allalasandra GKVK Post, Yelahanka, Bengaluru 560065, India.
Ghada Al BerakdarDepartment of Dentistry, University Medical Services Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Elmoiz Merghni MkawiDepartment of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Manasa NuneManipal Institute of Regenerative Medicine (MIRM), Manipal Academy of Higher Education (MAHE), Allalasandra GKVK Post, Yelahanka, Bengaluru 560065, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regenerative medicine is a field that aims to influence and improvise the processes of tissue repair and restoration and to assist the body to heal and recover. In the field of hard tissue regeneration, bio-inert materials are being predominantly used, and there is a necessity to use bioactive materials that can help in better tissue-implant interactions and facilitate the healing and regeneration process. One such bioactive material that is being focused upon and studied extensively in the past few decades is bioactive glass (BG). The original bioactive glass (45S5) is composed of silicon dioxide, sodium dioxide, calcium oxide, and phosphorus pentoxide and is mainly referred to by its commercial name Bioglass. BG is mainly used for bone tissue regeneration due to its osteoconductivity and osteostimulation properties. The bioactivity of BG, however, is highly dependent on the compositional ratio of certain glass-forming system content. The manipulation of content ratio and the element compositional flexibility of BG-forming network developed other types of bioactive glasses with controllable chemical durability and chemical affinity with bone and bioactivity. This review article mainly discusses the basic information about silica-based bioactive glasses, including their composition, processing, and properties, as well as their medical applications such as in bone regeneration, as bone grafts, and as dental implant coatings.

Indexed as

bioactive glasseshard tissue regenerationmedical applicationsosteoconductivityosteostimulationregenerative medicine

Identifiers

PMID33498229
PMCPMC7909272

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.