ArticleDiagnostics (Basel, Switzerland)2021
DGEMRIC in the Assessment of Pre-Morphological Cartilage Degeneration in Rheumatic Disease: Rheumatoid Arthritis vs. Psoriatic Arthritis.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Ultrasound grayscale histogram analysis for early rheumatoid arthritis cartilage assessment.Advances in rheumatology (London, England) · 2025Article
- The semiquantitative assessment of metacarpal head cartilage damage in rheumatoid arthritis via ultrahigh frequency ultrasound.Quantitative imaging in medicine and surgery · 2025Article
- Insights into the Age Dependency of Compositional MR Biomarkers Quantifying the Health Status of Cartilage in Metacarpophalangeal Joints.Diagnostics (Basel, Switzerland) · 2023Article
- Quantification of Sodium Relaxation Times and Concentrations as Surrogates of Proteoglycan Content of Patellar CARTILAGE at 3T MRI.Diagnostics (Basel, Switzerland) · 2021Article
- Imaging update in inflammatory arthritis.Journal of clinical orthopaedics and trauma · 2021Article
- Longitudinal T2 Mapping and Texture Feature Analysis in the Detection and Monitoring of Experimental Post-Traumatic Cartilage Degeneration.Life (Basel, Switzerland) · 2021Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundEven though cartilage loss is a known feature of psoriatic (PsA) and rheumatoid arthritis (RA), research is sparse on its role in the pathogenesis of PsA, its potential use for disease monitoring and for differentiation from RA. We therefore assessed the use of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) to evaluate biochemical cartilage changes in metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints in PsA patients and compared these to RA patients. MATERIALS AND
methodsA total of 17 patients with active PsA and 20 patients with active RA were evaluated by high-resolution 3 Tesla dGEMRIC using a dedicated 16-channel hand coil. Images were analyzed by two independent raters for dGEMRIC indices and joint space width (JSW) at MCP and PIP joint levels.
resultsNo significant differences of dGEMRIC values could be found between both study populations (PsA 472.25 ms, RA 461.11 ms;
conclusionsAs evaluated by dGEMRIC, the molecular composition of the MCP and PIP joint cartilage of PsA patients is similar to that of RA patients, demonstrating the scientific and clinical feasibility of compositional magnetic resonance (MR) imaging in these disease entities. Patterns and severity of compositional cartilage degradation of the finger joints may therefore be assessed beyond mere morphology in PsA and RA patients.
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