ReviewInternational journal of molecular sciences2021
Legacy and Emerging Per- and Polyfluoroalkyl Substances: Analytical Techniques, Environmental Fate, and Health Effects.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exposure to Per- and Polyfluoroalkyl Substances and Liver Cancer: A Systematic Review of Animal and Epidemiological Studies.Environmental science & technology · 2026Pooled it
- Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- Integrating Computational Chemistry and Ion Mobility Spectrometry into Non-Targeted Analysis Workflows for the Structural Elucidation of Emerging PFAS.Journal of the American Society for Mass Spectrometry · 2026Article
- Perfluoroether Peptide-Modified Artificial Viral Capsid for Enhanced Doxorubicin Delivery to Liver Cancer Cells.ACS omega · 2026Article
- AOP-Based Analysis of Curated Transcriptomic Data Reveals a Context-Dependent Core Mechanism of PFAS-Induced Liver Steatosis.Environmental science & technology · 2026Article
- Vapor-Phase Detection of Perfluoroalkyl Acids using Amplifying Fluorescent Polymers.Small methods · 2026Article
- GenX exposure induces neurodevelopmental impairment and synaptic toxicity in hESC-derived cerebral organoids.Materials today. Bio · 2026Article
- Unveiling the structural determinants of PFASs acute inhalation toxicity: an integrated approach using QSAR, q-RASAR, and interspecies extrapolation.Archives of toxicology · 2026Article
- Incomplete versus Sustained Innate-Immune Responses in the Medicinal Leech following Chronic, Environmentally Relevant Per- and Polyfluoroalkyl Substance Exposure.Environment & health (Washington, D.C.) · 2026Article
- Occurrence of per- and polyfluoroalkyl substances (PFAS) and their precursors in biosolids across 15 U.S. states.Environmental science and pollution research international · 2026Article
- Environmental Exposure to Emerging Per- and Polyfluoroalkyl Substances and Cardiovascular Diseases: A Mixture Analysis.Health science reports · 2026Article
- Home-Produced Eggs as Indicators of PFAS Contamination in Food Following a Fire at a Plastic Recycling Plant.Foods (Basel, Switzerland) · 2026Article
- [Determination of 31 perfluoroalkyl and polyfluoroalkyl substances in water by ultra performance liquid chromatography-triple quadrupole mass spectrometry combined with direct injection].Se pu = Chinese journal of chromatography · 2026Article
- Development of a QSAR model for predicting PPARα activation by PFAS based on human in vitro data of a comprehensive panel of legacy and novel PFAS.Archives of toxicology · 2026Article
- Per- and polyfluoroalkyl substances (PFAS): persistence, toxicity, and emerging solutions.Bioprocess and biosystems engineering · 2026Review
- Current Status of Per- and Poly-Fluoroalkyl Substances (PFAS) Exposure on Lung Cell Biology and Pulmonary Outcomes along Human Health Risk Assessment Steps.Current allergy and asthma reports · 2026Review
- Per- and Polyfluoroalkyl Substances and Endometriosis: A Systematic Review and Meta-Analysis.Toxics · 2026Review
- PFAS Pesticides: Contamination Pathways in Italy and the Need for Integrated Regulation.Toxics · 2026Article
- PFAS Removal During Pyrolysis of Biosolids Is Affected by Initial PFAS Concentration and Pyrolysis Efficiency.Water environment research : a research publication of the Water Environment Federation · 2026Article
- Eco-Friendly Sample Preparation Trends for Exogenous Toxic Organic Compounds in Food: A Sustainable Perspective for LC-MS Analysis.Foods (Basel, Switzerland) · 2026Review
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Due to their unique chemical properties, per- and polyfluoroalkyl substances (PFAS) have been used extensively as industrial surfactants and processing aids. While several types of PFAS have been voluntarily phased out by their manufacturers, these chemicals continue to be of ecological and public health concern due to their persistence in the environment and their presence in living organisms. Moreover, while the compounds referred to as "legacy" PFAS remain in the environment, alternative compounds have emerged as replacements for their legacy predecessors and are now detected in numerous matrices. In this review, we discuss the historical uses of PFAS, recent advances in analytical techniques for analysis of these compounds, and the fate of PFAS in the environment. In addition, we evaluate current biomonitoring studies of human exposure to legacy and emerging PFAS and examine the associations of PFAS exposure with human health impacts, including cancer- and non-cancer-related outcomes. Special focus is given to short-chain perfluoroalkyl acids (PFAAs) and ether-substituted, polyfluoroalkyl alternatives including hexafluoropropylene oxide dimer acid (HFPO-DA; tradename GenX), 4,8-dioxa-3H-perfluorononanoic acid (DONA), and 6:2 chlorinated polyfluoroethersulfonic acid (6:2 Cl-PFESA; tradename F-53B).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.