Evidence map›Paper›PMID 33498179›Full record

ArticleInternational journal of molecular sciences2021

Identification of Sortilin Alternatively Spliced Variants in Mouse 3T3L1 Adipocytes.

Ashley Lui, Robert Sparks, Rekha Patel, Niketa A Patel

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ashley LuiDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0003-4090-4680
Robert SparksDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Rekha PatelResearch Service, James A. Haley Veteran's Hospital, Tampa, FL 33612, USA.
Niketa A PatelDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0003-4811-8596
University of South Florida · USJames A. Haley Veterans' Hospital · US

Funding

Adipose stem cells' niche in obesityI01BX003836 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI Niketa A. Patel · 2017 to 2026
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BLRD Research Career Scientist Award ApplicationIK6BX005387 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI PATEL, NIKETA A. · 2021 to 2025
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BLRD VA I01 BX003836BLRD VA IK6 BX005387U.S. Department of Veterans Affairs VAMR I01BX003836U.S. Department of Veterans Affairs VA RCS IK6BX005387
6 · The paper itself

Abstract

Type 2 diabetes mellitus is a metabolic disorder defined by systemic insulin resistance. Insulin resistance in adipocytes, an important regulator of glucose metabolism, results in impaired glucose uptake. The trafficking protein, sortilin, regulates major glucose transporter 4 (Glut4) movement, thereby promoting glucose uptake in adipocytes. Here, we demonstrate the presence of an alternatively spliced sortilin variant (Sort

Indexed as

Alternative Splicing3T3-L1 CellsAdaptor Proteins, Vesicular TransportAdipocytesAnimalsBinding SitesGlucoseInsulin ResistanceIntrinsically Disordered ProteinsMiceMolecular Dynamics SimulationProtein BindingProtein DomainsSortilinAdaptor Proteins, Vesicular TransportGlucoseIntrinsically Disordered ProteinsSortilinadipocytesalternative splicingGlut4molecular dynamicsprotein–protein dockingSortilin

Identifiers

PMID33498179
PMCPMC7863940
OpenAlexW3122375989

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.