Trial reportOphthalmology2021
Anatomic Changes and Predictors of Angle Widening after Laser Peripheral Iridotomy: The Zhongshan Angle Closure Prevention Trial.
Trial report in Ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Iridotomy to slow progression of visual field loss in angle-closure glaucoma.The Cochrane database of systematic reviews · 2023Pooled it
- Ocular Biometric Risk Factors for Progression of Primary Angle Closure Disease: The Zhongshan Angle Closure Prevention Trial.Ophthalmology · 2022Trial
- PACS plus stratification of acute angle closure glaucoma cases: a retrospective analysis.Eye (London, England) · 2026Article
- Risk prediction in primary angle closure suspects: current perspectives.Annals of translational medicine · 2026Article
- Changes in anterior segment parameters after laser peripheral iridotomy in patients with primary angle closure suspect.Frontiers in medicine · 2026Article
- Investigation of laser peripheral iridotomy characteristics using the ImageJ program on anterior segment parameters.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Effect of mydriasis on anterior segment biometric parameters of patients with age-related cataracts.BMC ophthalmology · 2025Article
- AS-OCTA-Guided Versus Slit Lamp-Guided Laser Peripheral Iridotomy for Primary Angle-Closure Suspect Patients: A Short-Term Result.Translational vision science & technology · 2025Article
- Determinative role of anterior segment optical coherence tomography bioparameters in the pathogenesis of asymmetrical primary angle closure disease.BMC ophthalmology · 2025Article
- Longitudinal Trends in Resource Utilization Associated With Newly Diagnosed Primary Angle Closure Glaucoma in the United States.Journal of glaucoma · 2025Article
- Proposed Nomenclature for Landmarks in Anterior-Segment OCT: The APOSTEL-AS Panel Consensus.JAMA ophthalmology · 2025Article
- Five-year effect of sequential argon-Nd:YAG prophylactic laser peripheral iridotomy on corneal endothelial cell density in Japanese eyes with narrow angles.Japanese journal of ophthalmology · 2025Observational
- Automated expert-level scleral spur detection and quantitative biometric analysis on the ANTERION anterior segment OCT system.The British journal of ophthalmology · 2024Article
- Practice Patterns and Sociodemographic Disparities in the Clinical Care of Anatomical Narrow Angles in the United States.American journal of ophthalmology · 2024Article
- Analysis of Indicators for Assessing the Risk of Progression from PACS to APAC and the Degree of Intraocular Pressure Elevation in APAC Using AS-OCT.Journal of ophthalmology · 2024Article
- Biometric Risk Factors for Angle Closure Progression After Laser Peripheral Iridotomy.JAMA ophthalmology · 2023Article
- Factors defining the intraocular pressure-lowering effect of phacoemulsification and laser peripheral iridotomy in patients with primary angle closure : Factors defining IOP lowering effect of PE and LPI in PAC.Lasers in medical science · 2023Article
- A Mechanistic Model of Aqueous Humor Flow to Study Effects of Angle Closure on Intraocular Pressure.Translational vision science & technology · 2023Article
- Clinical implication of recent randomized control trial in primary angle-closure disease management.Indian journal of ophthalmology · 2022Review
- Biometric indicators of anterior segment parameters before and after laser peripheral iridotomy by swept-source optical coherent tomography.BMC ophthalmology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 4 countries.
Funding
Abstract
purposeTo assess anatomic changes after laser peripheral iridotomy (LPI) and predictors of angle widening based on anterior segment (AS) OCT and angle opening based on gonioscopy.
designProspective observational study.
participantsPrimary angle-closure suspects (PACSs) 50 to 70 years of age.
methodsParticipants of the Zhongshan Angle Closure Prevention (ZAP) Trial underwent gonioscopy and AS-OCT imaging at baseline and 2 weeks after LPI. Primary angle-closure suspect was defined as the inability to visualize pigmented trabecular meshwork in 2 or more quadrants on static gonioscopy. Laser peripheral iridotomy was performed on 1 eye per patient in superior (between 11 and 1 o'clock) or temporal or nasal locations (at or below 10:30 or 1:30 o'clock). Biometric parameters in horizontal and vertical AS-OCT scans were measured and averaged. Linear and logistic regression modeling were performed to determine predictors of angle widening, defined as change in mean angle opening distance measured at 750 μm from the scleral spur (AOD
main outcome measuresAnatomic changes and predictors of angle widening and opening after LPI.
resultsFour hundred fifty-four patients were included in the analysis. Two hundred nineteen underwent superior LPI and 235 underwent temporal or nasal LPI. Significant changes were found among most biometric parameters (P < 0.006) after LPI, including greater AOD
conclusionsSuperior LPI location results in significantly greater angle widening compared with temporal or nasal locations in a Chinese population with PACS. This supports consideration of superior LPI locations to optimize anatomic changes after LPI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.