Evidence map›Paper›PMID 33497630›Full record

ArticleCurrent biology : CB2021

Pupillary light reflex of lamprey Petromyzon marinus.

Ala Morshedian, Theodore Henry Huynh, Rikard Frederiksen, Gordon L Fain, Alapakkam P Sampath

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ala MorshedianJules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-7000, USA.
Theodore Henry HuynhJules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-7000, USA.
Rikard FrederiksenJules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-7000, USA.
Gordon L FainJules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-7000, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095-7000, USA. Electronic address: gfain@ucla.edu.
Alapakkam P SampathJules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-7000, USA. Electronic address: asampath@jsei.ucla.edu.

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, DAVID S WILLIAMS · 1985 to 2026
$16.8M
PHYSIOLOGY OF PHOTORECEPTORSR01EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORDON Lee FAIN · 1985 to 2026
$9.9M
Molecular Mechanisms of Photoreceptor AdaptationR01EY029817 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAMPATH, ALAPAKKAM P · 2019 to 2023
$2.1M
MOLECULAR GENETICS OF EARLY EYE DEVELOPMENTZ01EY000311 · NEI · NATIONAL EYE INSTITUTE · PI TOMAREV, STANISLAV I · 1996 to 2008
$941k
Intramural NIH HHS Z01 EY000311NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY001844NEI NIH HHS R01 EY029817
6 · The paper itself

Abstract

The discoveries of the photopigment melanopsin and intrinsically photosensitive retinal ganglion cells (ipRGCs) have revealed novel mechanisms of light detection now known to control several kinds of non-image-forming vision, including regulation of mood, the circadian rhythm, and the pupillary light reflex (PLR). These remarkable discoveries have been made mostly on mammals, but many vertebrates express melanopsin and adjust the diameter of the pupil to the ambient light intensity to extend the operating range of vision and reduce spherical aberration

Indexed as

AnimalsMelanopsinPetromyzonReflex, PupillaryRetinal Ganglion CellsRetinal Horizontal CellsRod OpsinsVision, OcularMelanopsinRod Opsins

Identifiers

PMID33497630
PMCPMC9406759

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.