Evidence map›Paper›PMID 33497610›Full record

ReviewCell2021

Adaptive immunity to SARS-CoV-2 and COVID-19.

Alessandro Sette, Shane Crotty

2 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1,199 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,199citing papers in PubMed, 4 pooled it
113.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05038475 unknown statusnot on this map

Longitudinal Observation of Clinical and Immunological Profiles After SARS-Cov-2 Infection

TypeobservationalSponsorAssociation "Naso Sano" OnlusRan2020 to 2024Enrolled100ConditionsCovid19, SARS-CoV2 Infection, Olfactory Disorder, COVID-19ArmsCOVID-19 antibody test
NCT05116748 completednot on this map

Safety and Immunogenicity of the SARS-CoV2 Vaccine in Solid Organ Transplantation (Lung and / or Liver) Adult Recipients

TypeobservationalSponsorFondazione IRCCS Ca' Granda, Ospedale Maggiore PoliclinicoRan2021 to 2023Enrolled364ConditionsCOVID-19, Vaccine Adverse Reaction, Vaccine Response Impaired, Vaccine ReactionArmsCOVID19 mRNA vaccine
3 · Its place in the literature

Who cites it

1,199 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,986 citations in OpenAlex.

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1,139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Alessandro SetteCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Shane CrottyCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA. Electronic address: shane@lji.org.
La Jolla Institute for Immunology · USUniversity of California, San Diego · US

Funding

T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitisU19AI142742 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Alessandro Sette · 2019 to 2026
$32.8M
NIAID NIH HHS U19 AI142742
6 · The paper itself

Abstract

The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of antibodies), CD4

Indexed as

Adaptive ImmunityAge FactorsB-LymphocytesClinical Trials as TopicCOVID-19COVID-19 VaccinesHumansImmunologic MemoryPost-Acute COVID-19 SyndromeRace FactorsSARS-CoV-2Sex FactorsT-Lymphocyte SubsetsViral LoadCOVID-19 Vaccines

Identifiers

PMID33497610
PMCPMC7803150
OpenAlexW3119858919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.