ArticleMovement disorders : official journal of the Movement Disorder Society2021
Increased Climbing Fiber Lateral Crossings on Purkinje Cell Dendrites in the Cerebellar Hemisphere in Essential Tremor.
Article in Movement disorders : official journal of the Movement Disorder Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study.Annals of clinical and translational neurology · 2024Trial
- Purkinje Cell Loss and Changes in Basket Cell Morphology in Essential Tremor and Other Cerebellar Degenerative Diseases: A Postmortem Study of 332 Brains.Cerebellum (London, England) · 2026Article
- Article
- Targeting the fundamentals for tremors: the frequency and amplitude coding in essential tremor.Journal of biomedical science · 2025Review
- Clinical Heterogeneity of Essential Tremor: Understanding Neural Substrates of Action Tremor Subtypes.Cerebellum (London, England) · 2024Review
- Review
- Reduced Bergmann glial process terminations and lateral appendages in essential tremor.Annals of clinical and translational neurology · 2024Article
- Ataxias: Hereditary, Acquired, and Reversible Etiologies.Seminars in neurology · 2023Article
- The differences in clinical characteristics and natural history between essential tremor and essential tremor plus.Scientific reports · 2022Article
- Essential tremor: Clinical perspectives and pathophysiology.Journal of the neurological sciences · 2022Review
- Essential tremor: Is this an electrical or a degenerative disorder? Or is it both?International review of neurobiology · 2022Article
- A standardized accelerometry method for characterizing tremor: Application and validation in an ageing population with postural and action tremor.Frontiers in neuroinformatics · 2022Article
- Is the inferior olive central to essential tremor? Yes.International review of neurobiology · 2022Article
- Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder.International review of neurobiology · 2022Article
- What's in a Name? Nomenclature of essential tremor: Syndrome or family of diseases?International review of neurobiology · 2022Article
- Essential tremor.Nature reviews. Disease primers · 2021Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundClimbing fibers (CFs) innervate Purkinje cells (PCs) with 1:1 relationship to ensure proper cerebellar function. Although CFs abnormally extend into the parallel fiber domain of PC dendrites in essential tremor (ET), the architecture of CFs in relation to PCs has yet to be investigated in detail.
objectiveThe aim of this work was to study the architecture of CFs in relation to PCs in ET.
methodsThe number of PC somas and PC dendrites that a single CF crossed was quantified in the postmortem cerebellum of 15 ET cases and 15 control cases.
resultsIn ET, CFs crossed a greater number of PC somas and PC dendrites than in control cases, raising the possibility that there is abnormal CF wiring onto the PCs. Interestingly, the increase in CF-PC crossings positively correlated with tremor severity.
conclusionsPatients with ET have increased CF crossings on PC dendrites. This abnormal architectural arrangement may contribute to synchronous brain activity and tremor. © 2021 International Parkinson and Movement Disorder Society.
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Registered trials
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