Evidence map›Paper›PMID 33497493›Full record

ArticleHematological oncology2021

FZD6 triggers Wnt-signalling driven by WNT10B

Adriana Cassaro, Giovanni Grillo, Marco Notaro, Jessica Gliozzo, Ilaria Esposito, Gianluigi Reda, Alessandra Trojani, Giorgio Valentini, Barbara Di Camillo, Roberto Cairoli and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hematological oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. The role of Evi/Wntless in exporting Wnt proteins.Development (Cambridge, England) · 2023
    Review
  3. The role of WNT10B in physiology and disease: A 10-year update.Frontiers in cell and developmental biology · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. FZD6 triggers Wnt-signalling driven by WNT10BHematological oncology · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Adriana CassaroDepartment of Health Sciences, University of Milan, Milan, Italy.
Giovanni GrilloDepartment of Oncology, Hematology Unit, Niguarda Hospital, Milan, Italy.
Marco NotaroDepartment of Computer Science "Giovanni degli Antoni", University of Milan, Milan, Italy.
Jessica GliozzoDepartment of Computer Science "Giovanni degli Antoni", University of Milan, Milan, Italy.
Ilaria EspositoDepartment of Health Sciences, University of Milan, Milan, Italy.
Gianluigi RedaDepartment of Oncology, Hematology Unit, Ospedale Maggiore Policlinico, Milan, Italy.
Alessandra TrojaniDepartment of Oncology, Hematology Unit, Niguarda Hospital, Milan, Italy.
Giorgio ValentiniDepartment of Computer Science "Giovanni degli Antoni", University of Milan, Milan, Italy.
Barbara Di CamilloInformation Engineering Department, University of Padova, Padova, Italy.
Roberto CairoliDepartment of Oncology, Hematology Unit, Niguarda Hospital, Milan, Italy.
Alessandro BeghiniDepartment of Health Sciences, University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0002-8234-3474
University of Milan · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Padua · IT

Funding

Fondazione Regionale per la Ricerca Biomedica FRRB 2015LGK974 Drug SupplyLions Club Milano Host 2017Novartis Pharma 2017
6 · The paper itself

Abstract

Wnt/Fzd signaling has been implicated in hematopoietic stem cell maintenance and in acute leukemia establishment. In our previous work, we described a recurrent rearrangement involving the WNT10B locus (WNT10B

Indexed as

Gene Expression Regulation, LeukemicWnt Signaling PathwayAcyltransferasesFemaleFrizzled ReceptorsHeLa CellsHumansMaleMembrane ProteinsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaProto-Oncogene ProteinsPyrazinesPyridinesWnt ProteinsAcyltransferasesFrizzled ReceptorsFZD6 protein, humanLGK974Membrane ProteinsPORCN protein, humanProto-Oncogene ProteinsPyrazinesPyridinesWNT10B protein, humanWnt ProteinsFZD6LGK974porcupine inhibitorT-ALLWNT10BWnt signaling

Identifiers

PMID33497493
PMCPMC8451758
OpenAlexW3122372771

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.