ArticlePloS one2021
The association of body mass index with functional dyspepsia is independent of psychological morbidity: A cross-sectional study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations.Journal of gastroenterology and hepatology · 2026Pooled it
- Examining the Association Between Overweight, Obesity, and Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Global prevalence of functional dyspepsia according to Rome criteria, 1990-2020: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Sexual dysfunction worsens both the general and specific quality of life of women with irritable bowel syndrome. A cross-sectional study.BMC women's health · 2023Trial
- Associations of Functional Dyspepsia with Eating Behaviors and Stress-Coping Styles Among Japanese University Students.Nutrients · 2026Article
- Clinical Relevance of Gastric Emptying Time in Functional Dyspepsia.Journal of neurogastroenterology and motility · 2025Article
- Factors Associated with Overlap between Functional Dyspepsia and Nonerosive Reflux Disease in Endoscopy-based Helicobacter pylori-uninfected Japanese Health Checkup Participants: A Prospective, Multicenter Cross-sectional Study.Internal medicine (Tokyo, Japan) · 2024Article
- Prevalence and predictors of functional gastrointestinal disorder among the undergraduate students of Bangladesh.PloS one · 2024Article
- The associations between functional dyspepsia and potential risk factors: A comprehensive Mendelian randomization study.PloS one · 2024Article
- Association of vitamin D and functional dyspepsia: a case-control study.Annals of medicine and surgery (2012) · 2023Article
- Association between body mass index and irritable bowel syndrome in the young Japanese population: a cross-sectional study.International journal of colorectal disease · 2022Article
- Association Between Body Mass Index and Functional Dyspepsia in Young Japanese People.Journal of neurogastroenterology and motility · 2022Article
- Moxibustion Regulates Gastrointestinal Motility via HCN1 in Functional Dyspepsia Rats.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
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4 authors.
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Abstract
BACKGROUND AND
aimThe association between body mass index (BMI) and functional gastrointestinal disorders (FGIDs) has been inconsistent. We aimed to explore the association of BMI with FGIDs in a primary care setting to provide more data in this area.
methodsA cross-sectional study of consecutive Asian adults attending a primary healthcare setting was conducted. This study was conducted in 2 phases: The association between BMI and common FGIDs (functional diarrhea/FD, irritable bowel syndrome/IBS, functional diarrhea and functional constipation/FC) was studied initially. The influence of anxiety and depression on BMI and FGIDs was additionally explored in phase 2.
resultsA total of 1002 subjects (median age 32 years, 65.4% females, 90.7% Malay ethnicity, 73.2% higher than secondary level education) were recruited between August 2019 to January 2020. The majority of subjects were obese (39.2%), and had central obesity (51.7%), while 6.1% had metabolic syndrome. The prevalence of FD, IBS, functional diarrhea and FC were 7.5% (n = 75), 4.0% (n = 40), 1.2% (n = 12) and 10.5% (n = 105) respectively, based on the Rome III criteria. Among individual FGIDs, FD subjects had more underweight adults (BMI<18.5kg/m2) compared to controls (13.3% vs 3.5%, P = 0.002) and being underweight remained as an independent association with FD [OR = 3.648 (95%CI 1.494-8.905), P = 0.004] at multi-variate analysis. There were no independent associations between BMI and other FGIDs. When psychological morbidity was additionally explored, anxiety (OR 2.032; 95%CI = 1.034-3.991, p = 0.040), but not depression, and a BMI<18.5kg/m2 (OR 3.231; 95%CI = 1.066-9.796, p = 0.038) were found to be independently associated with FD.
conclusionsFD, but not other FGIDs, is associated with being underweight. This association is independent of the presence of anxiety.
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