Evidence map›Paper›PMID 33497317›Full record

ArticleRadiology2021

Six-month Follow-up Chest CT Findings after Severe COVID-19 Pneumonia.

Xiaoyu Han, Yanqing Fan, Osamah Alwalid, Na Li, Xi Jia, Mei Yuan, Yumin Li, Yukun Cao, Jin Gu, Hanping Wu and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05823896 (An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult Participants Suffering from Post-COVID), which is not on this map. Cited by 363 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
363citing papers in PubMed, 6 pooled it
38.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05823896 phase2completednot on this mapstarted 2023, after this paper: background citation

An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult Participants Suffering from Post-COVID

TypeinterventionalSponsorKarolinska InstitutetRan2023 to 2024Enrolled219ConditionsPost-COVID-19 Syndrome, Long COVID, Long Covid19, COVID-19ArmsNirmatrelvir/ritonavir, Placebo/ritonavir
3 · Its place in the literature

Who cites it

363 citing papers in PubMed, 6 syntheses or guidelines pooled it, 646 citations in OpenAlex.

  1. Pooled it
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  3. Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2025
    Pooled it
  4. Pooled it
  5. SARS-CoV-2 post-acute sequelae in previously hospitalised patients: systematic literature review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  6. Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
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  20. Incentive Spirometer in COVID-19: A Systematic Review.Journal of clinical medicine · 2026
    Review

303 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Xiaoyu Han *From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China (Y.F.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (H.W.).ORCID 0000-0001-6121-596X
Yanqing Fan *From the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China (Y.F.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (H.W.).
Osamah AlwalidFrom the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China (Y.F.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (H.W.).ORCID 0000-0001-9930-0932
Na LiFrom the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China (Y.F.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (H.W.).
Xi JiaFrom the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China (Y.F.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (H.W.).
Mei YuanFrom the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China (Y.F.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (H.W.).
Yumin LiFrom the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China (Y.F.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (H.W.).
Yukun CaoFrom the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China (Y.F.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (H.W.).ORCID 0000-0002-8391-841X
Jin GuFrom the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China (Y.F.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (H.W.).
Hanping WuFrom the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China (Y.F.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (H.W.).ORCID 0000-0002-3028-859X
Heshui ShiFrom the Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, People's Republic of China (X.H., O.A., N.L., X.J., M.Y., Y.L., Y.C., J.G., H.S.); Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China (Y.F.); and Department of Radiology, Michigan Medicine, University of Michigan, Ann Arbor, Mich (H.W.).ORCID 0000-0001-7644-3711
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing · CNJinyintan Hospital · CNMichigan Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Little is known about the long-term lung radiographic changes in patients who have recovered from coronavirus disease 2019 (COVID-19), especially those with severe disease. Purpose To prospectively assess pulmonary sequelae and explore the risk factors for fibrotic-like changes in the lung at 6-month follow-up chest CT of survivors of severe COVID-19 pneumonia. Materials and Methods A total of 114 patients (80 [70%] men; mean age, 54 years ± 12) were studied prospectively. Initial and follow-up CT scans were obtained a mean of 17 days ± 11 and 175 days ± 20, respectively, after symptom onset. Lung changes (opacification, consolidation, reticulation, and fibrotic-like changes) and CT extent scores (score per lobe, 0-5; maximum score, 25) were recorded. Participants were divided into two groups on the basis of their 6-month follow-up CT scan: those with CT evidence of fibrotic-like changes (traction bronchiectasis, parenchymal bands, and/or honeycombing) (group 1) and those without CT evidence of fibrotic-like changes (group 2). Between-group differences were assessed with the Fisher exact test, two-sample

Indexed as

COVID-19FemaleFibrosisFollow-Up StudiesHumansLongitudinal StudiesLungMaleMiddle AgedProspective StudiesSARS-CoV-2Tomography, X-Ray Computed

Identifiers

PMID33497317
PMCPMC7841877
OpenAlexW3121686146

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.