Evidence map›Paper›PMID 33497197›Full record

ReviewACS nano2021

Hybrid Nanosystems for Biomedical Applications.

Joshua Seaberg, Hossein Montazerian, Md Nazir Hossen, Resham Bhattacharya, Ali Khademhosseini, Priyabrata Mukherjee

Abstract readReview
In one paragraph

Review in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Lipid and polymeric nanocarriers for siRNA delivery to the brain.Journal of controlled release : official journal of the Controlled Release Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joshua SeabergDepartment of Pathology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, United States.
Hossein MontazerianDepartment of Bioengineering, University of California-Los Angeles, Los Angeles, California 90095, United States.
Md Nazir HossenDepartment of Pathology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, United States.
Resham BhattacharyaDepartment of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, United States.
Ali KhademhosseiniTerasaki Institute for Biomedical Innovation (TIBI), Los Angeles, California 90024, United States.
Priyabrata MukherjeeDepartment of Pathology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, United States.ORCID 0000-0002-0557-0833

Funding

Molecular Mechanism of Antiangiogenic Properties of Gold NanoparticleR01CA136494 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MUKHERJEE, PRIYABRATA · 2009 to 2020
$2.9M
Normalizing aberrant metabolism in ovarian cancer by a unique drug delivery systemR01CA253391 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BHATTACHARYA, RESHAM, MUKHERJEE, PRIYABRATA · 2021 to 2025
$1.7M
Reprogramming Tumor Microenvironment by NanoparticleR01CA213278 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MUKHERJEE, PRIYABRATA · 2017 to 2021
$1.7M
Exploiting gold nanoparticle as a probe to identify therapeutic targetsR01CA260449 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Resham Bhattacharya, Priyabrata Mukherjee · 2022 to 2026
$1.6M
NCI NIH HHS R01 CA136494NCI NIH HHS R01 CA213278NCI NIH HHS R01 CA253391NCI NIH HHS R01 CA260449
6 · The paper itself

Abstract

Inorganic/organic hybrid nanosystems have been increasingly developed for their versatility and efficacy at overcoming obstacles not readily surmounted by nonhybridized counterparts. Currently, hybrid nanosystems are implemented for gene therapy, drug delivery, and phototherapy in addition to tissue regeneration, vaccines, antibacterials, biomolecule detection, imaging probes, and theranostics. Though diverse, these nanosystems can be classified according to foundational inorganic/organic components, accessory moieties, and architecture of hybridization. Within this Review, we begin by providing a historical context for the development of biomedical hybrid nanosystems before describing the properties, synthesis, and characterization of their component building blocks. Afterward, we introduce the architectures of hybridization and highlight recent biomedical nanosystem developments by area of application, emphasizing hybrids of distinctive utility and innovation. Finally, we draw attention to ongoing clinical trials before recapping our discussion of hybrid nanosystems and providing a perspective on the future of the field.

Indexed as

Drug Delivery SystemsPhototherapybiomedical nanosystemsbiomolecular sensorsdrug deliverygene therapyhybrid nanoparticlehybrid nanosysteminorganic/organic hybridizationnanomaterialsphototherapytheranostics

Identifiers

PMID33497197
PMCPMC9521743

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.