Evidence map›Paper›PMID 33497171›Full record

SynthesisCanadian journal of surgery. Journal canadien de chirurgie2021

Clinical effectiveness of therapy with continuous-flow left ventricular assist devices in nonischemic versus ischemic cardiomyopathy: a systematic review and meta-analysis.

Christopher Wavell, Andrew Sokolowski, Michelle L Klingel, Charles Yin, A Dave Nagpal

Open access · diamondAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Canadian journal of surgery. Journal canadien de chirurgie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Christopher WavellFrom the Division of Cardiac Surgery, Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Wavell, Sokolowski, Yin); The Hospital for Sick Children, Toronto, Ont. (Klingel); Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Yin); and the Division of Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Nagpal).
Andrew SokolowskiFrom the Division of Cardiac Surgery, Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Wavell, Sokolowski, Yin); The Hospital for Sick Children, Toronto, Ont. (Klingel); Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Yin); and the Division of Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Nagpal).
Michelle L KlingelFrom the Division of Cardiac Surgery, Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Wavell, Sokolowski, Yin); The Hospital for Sick Children, Toronto, Ont. (Klingel); Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Yin); and the Division of Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Nagpal).
Charles YinFrom the Division of Cardiac Surgery, Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Wavell, Sokolowski, Yin); The Hospital for Sick Children, Toronto, Ont. (Klingel); Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Yin); and the Division of Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Nagpal).
A Dave NagpalFrom the Division of Cardiac Surgery, Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Wavell, Sokolowski, Yin); The Hospital for Sick Children, Toronto, Ont. (Klingel); Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Yin); and the Division of Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Nagpal).
Hospital for Sick Children · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Clinicians may be less inclined to consider long-term left ventricular assist device (LVAD) therapy in end-stage heart failure (ESHF) as a result of nonischemic cardiomyopathy (NICM) versus ischemic cardiomyopathy (ICM) owing to potentially greater right ventricular involvement in the former; however, it is unknown whether the cause of heart failure has a clinically meaningful effect on outcomes following LVAD implantation. In this systematic review, we aimed to determine whether ischemic versus nonischemic etiology has any impact on patient-relevant outcomes. Methods: We searched MEDLINE, Embase, PubMed and the Cochrane Library for studies published in English between Jan. 1, 2000, and Nov. 22, 2018, that examined survival and transplantation rates following LVAD implantation in patients with NICM or ICM. Randomized clinical trials, cohort studies, case-control studies, cross-sectional studies and case series with a sample size of at least 8 patients were eligible for inclusion. To be included in the meta-analysis, outcomes had to include at least death reported at 30 days or 1 year after LVAD implantation. Quality of included studies was assessed by 2 independent reviewers using the Newcastle-Ottawa Quality Assessment Scale for Cohort Studies. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) quality-assessment tool was used to assess outcomes (30-d survival, 1-yr survival and cardiac transplantation following LVAD therapy) across studies. Results: From a total of 2843 citations identified, 7 studies met all inclusion criteria. Studies were generally of good quality, but reporting of patient demographic characteristics, outcomes and complications was heterogeneous. We found no significant difference in 30-day or 1-year survival or in cardiac transplantation rates after device implantation between the NICM and ICM groups. Patients in the 2 groups had similar outcomes up to 1 year with LVAD therapy. Conclusion: Early outcomes of LVAD therapy do not appear to be affected by heart failure etiology. Ongoing investigation is required to determine the long-term outcomes of LVAD therapy in ICM and NICM. Systematic review registration: PROSPERO register, record ID 76483.

Indexed as

Heart-Assist DevicesCardiomyopathiesHumansMyocardial IschemiaTreatment Outcome

Identifiers

PMID33497171
PMCPMC7955823
OpenAlexW3123618132

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.