Evidence map›Paper›PMID 33496902›Full record

Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2021

Development of an EORTC questionnaire measuring instrumental activities of daily living (IADL) in patients with brain tumours: phase I-III.

Quirien Oort, Linda Dirven, Sietske A M Sikkes, Neil Aaronson, Florien Boele, Christine Brannan, Jonas Egeter, Robin Grant, Martin Klein, Irene Lips and 9 more

Abstract readClinical Trial, Phase IClinical Trial, Phase IIClinical Trial, Phase III
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Quirien OortDepartment of Neurology and Brain Tumor Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, PO BOX 7057, 1007 MB, Amsterdam, The Netherlands. q.oort@amsterdamumc.nl.ORCID http://orcid.org/0000-0001-8130-4054
Linda DirvenDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Sietske A M SikkesDepartment of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Neil AaronsonDivision of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Florien BoeleLeeds Institute of Medical Research, St James's University Hospital, Leeds, LS9 7TF, UK.
Christine BrannanEast & North Hertfordshire NHS Trust Incorporating Mount Vernon Cancer Centre, Northwood, UK.
Jonas EgeterDepartment for Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria.
Robin GrantDepartment of Clinical Neurosciences, Western General Hospital, Edinburgh, UK.
Martin KleinDepartment of Medical Psychology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Irene LipsDepartment of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Yoshitaka NaritaDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center, Tokyo, Japan.
Hitomi SatoDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center, Tokyo, Japan.
Monika SztankayDepartment for Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria.
Günther StockhammerDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Andrea TalacchiDepartment of Neurosurgery, Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy.
Bernard M J UitdehaagDepartment of Neurology and Brain Tumor Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, PO BOX 7057, 1007 MB, Amsterdam, The Netherlands.
Jaap C ReijneveldDepartment of Neurology and Brain Tumor Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, PO BOX 7057, 1007 MB, Amsterdam, The Netherlands.
Martin J B TaphoornDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
EORTC Quality of Life Group

Funding

European Organisation for Research and Treatment of Cancer 004/2014
6 · The paper itself

Abstract

purposeBeing able to function independently in society is an important aspect of quality of life. This ability goes beyond self-care, requires higher order cognitive functioning, and is typically measured with instrumental activities of daily living (IADL) questionnaires. Cognitive deficits are frequently observed in brain tumour patients, however, IADL is almost never assessed because no valid and reliable IADL measure is available for this patient group. Therefore, this measure is currently being developed.

methodsThis international multicentre study followed European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group module development guidelines. Three out of four phases are completed: phases (I) generation of items, (II) construction of the item list, and (III) pre-testing. This paper reports the item selection procedures and preliminary psychometric properties of the questionnaire. Brain tumour patients (gliomas and brain metastases), their informal caregivers, and health care professionals (HCPs) were included.

resultsPhase I (n = 44 patient-proxy dyads and 26 HCPs) generated 59 relevant and important activities. In phase II, the activities were converted into items. In phase III (n = 85 dyads), the 59 items were pre-tested. Item selection procedures resulted in 32 items. Exploratory factor analysis revealed a preliminary dimensional structure consisting of five scales with acceptable to excellent internal consistency (α = 0.73-0.94) and two single items. For three scales, patients with cognitive impairments had significantly more IADL problems than patients without impairments.

conclusionA phase IV validation study is needed to confirm the psychometric properties of the EORTC IADL-BN32 questionnaire in a larger international sample.

Indexed as

Activities of Daily LivingBrain NeoplasmsFemaleHumansMaleMiddle AgedPsychometricsQuality of LifeSurveys and QuestionnairesBrain tumourDaily functioningIADLInstrumental activities of daily livingQuestionnaire

Identifiers

PMID33496902
PMCPMC8068708

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.