Evidence map›Paper›PMID 33496844›Full record

Observational studyArchives of gynecology and obstetrics2021

The potential association between a new angiogenic marker fractalkine and a placental vascularization in preeclampsia.

Grzegorz Szewczyk, Michał Pyzlak, Katarzyna Pankiewicz, Ewa Szczerba, Aleksandra Stangret, Dariusz Szukiewicz, Marta Skoda, Joanna Bierła, Bożena Cukrowska, Anna Fijałkowska

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Archives of gynecology and obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Chemokines in Pregnancy.Biomolecules · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Grzegorz SzewczykDepartment of General and Experimental Pathology, Medical University of Warsaw, Warsaw, Poland. grzegorz.szewczyk@wum.edu.pl.ORCID http://orcid.org/0000-0003-4143-2777
Michał PyzlakDepartment of Pathology, Maria Sklodowska-Curie Institute-Oncology Center, Warsaw, Poland.
Katarzyna PankiewiczDepartment of Obstetrics and Gynecology, Institute of Mother and Child, Warsaw, Poland.
Ewa SzczerbaDepartment of Cardiology, Institute of Mother and Child, Warsaw, Poland.
Aleksandra StangretDepartment of General and Experimental Pathology, Medical University of Warsaw, Warsaw, Poland.
Dariusz SzukiewiczDepartment of General and Experimental Pathology, Medical University of Warsaw, Warsaw, Poland.
Marta SkodaDepartment of General and Experimental Pathology, Medical University of Warsaw, Warsaw, Poland.
Joanna BierłaDepartment of Pathology, Children's Memorial Health Institute, Warsaw, Poland.
Bożena CukrowskaDepartment of Pathology, Children's Memorial Health Institute, Warsaw, Poland.
Anna FijałkowskaDepartment of Cardiology, Institute of Mother and Child, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeImpaired angiogenesis is one of the most common findings in preeclamptic placentas. A new angiogenetic role of fractalkine (CX3CL1) is recently recognized apart from inflammatory activity. In this study, a link between CX3CL1 and the development of placental vasculature in preeclampsia was examined.

methodsThe study comprised 52 women allocated to Group 1 (normotensive, n = 23) and Group 2 (preeclampsia, n = 29). In each group Doppler parameters, serum levels of CX3CL1, soluble fms-like tyrosine kinase-1 (sFlt-1), and placental growth factor (PlGF) were assessed between 30 and 32 week of pregnancy. After the delivery, placental samples were taken and the vascularization and expression of CX3CR1 receptor were assessed after immunostaining.

resultsCX3CL1 and sFlt-1 serum levels were significantly higher levels in Group 2 vs Group 1, while PlGF serum levels was significantly lower in Group 2. Lower cerebroplacental ratio (CPR) was observed in Group 2. The vascular/extravascular tissue index (V/EVTI) was significantly lower in Group 2, while compared to Group 1, with the lowest value in the fetus growth restriction (FGR) subgroup (0.18 ± 0.02; 0.24 ± 0.03; 0.16 ± 0.02, respectively). The expression of examined CX3CR1 was higher in Group 2, while compared to Group 1, reaching the highest values in FGR subgroup. There was a moderate negative correlation between birth weight, V/EVTI and CX3CL1 serum level and CX3CR1 placental expression in the group of pregnancies complicated with preeclampsia.

conclusionThe significant underdevelopment of placental vascular network in preeclampsia is associated with the change in the CX3CL1/CX3CR1 system, especially in FGR complicated pregnancies.

Indexed as

Pre-EclampsiaAdultBiomarkersCase-Control StudiesChemokine CX3CL1CX3C Chemokine Receptor 1FemaleHumansPlacentaPlacenta Growth FactorPregnancyProspective StudiesVascular Endothelial Growth Factor Receptor-1BiomarkersChemokine CX3CL1CX3C Chemokine Receptor 1CX3CR1 protein, humanFLT1 protein, humanPlacenta Growth FactorVascular Endothelial Growth Factor Receptor-1AngiogenesisFractalkinePlacentaPreeclampsia

Identifiers

PMID33496844
PMCPMC8277623

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.