ArticleBrain structure & function2021
Effect of corpus callosum agenesis on the language network in children and adolescents.
Article in Brain structure & function, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Tractography-based correlation of diffusion anisotropy metrics in chronic post-stroke aphasia.BMC medical imaging · 2026Article
- Developing brain asymmetry shapes cognitive and psychiatric outcomes in adolescence.Nature communications · 2025Article
- Review
- Sex Differences in White Matter Diffusivity in Children with Developmental Dyslexia.Children (Basel, Switzerland) · 2024Article
- Article
- Assessment of the corpus callosum size in male individuals with high intelligence quotient (members of Mensa International).Radiologie (Heidelberg, Germany) · 2023Article
- Fetal Neurology: From Prenatal Counseling to Postnatal Follow-Up.Diagnostics (Basel, Switzerland) · 2022Review
- Article
- White matter alterations and cognitive outcomes in children born very low birth weight.NeuroImage. Clinical · 2021Article
- Corpus callosum dysgenesis causes novel patterns of structural and functional brain connectivity.Brain communications · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
The present study is interested in the role of the corpus callosum in the development of the language network. We, therefore, investigated language abilities and the language network using task-based fMRI in three cases of complete agenesis of the corpus callosum (ACC), three cases of partial ACC and six controls. Although the children with complete ACC revealed impaired functions in specific language domains, no child with partial ACC showed a test score below average. As a group, ACC children performed significantly worse than healthy controls in verbal fluency and naming. Furthermore, whole-brain ROI-to-ROI connectivity analyses revealed reduced intrahemispheric and right intrahemispheric functional connectivity in ACC patients as compared to controls. In addition, stronger functional connectivity between left and right temporal areas was associated with better language abilities in the ACC group. In healthy controls, no association between language abilities and connectivity was found. Our results show that ACC is associated not only with less interhemispheric, but also with less right intrahemispheric language network connectivity in line with reduced verbal abilities. The present study, thus, supports the excitatory role of the corpus callosum in functional language network connectivity and language abilities.
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