Evidence map›Paper›PMID 33496365›Full record

ArticleCell proliferation2021

Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice.

Yeon Sun Kim, Seung Chel Yang, Mira Park, Youngsok Choi, Francesco J DeMayo, John P Lydon, Hye-Ryun Kim, Hyunjung Jade Lim, Haengseok Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yeon Sun KimDepartment of Biomedical Science, CHA University, Seongnam, Korea.
Seung Chel YangDepartment of Biomedical Science, CHA University, Seongnam, Korea.ORCID https://orcid.org/0000-0003-2027-0393
Mira ParkDepartment of Biomedical Science, CHA University, Seongnam, Korea.
Youngsok ChoiDepartment of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, Korea.
Francesco J DeMayoDepartment of Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
John P LydonDepartment of Molecular and Cellular Biology and Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA.
Hye-Ryun KimDepartment of Biomedical Science, CHA University, Seongnam, Korea.
Hyunjung Jade LimDepartment of Veterinary Medicine, School of Veterinary Medicine, Konkuk University, Seoul, Korea.
Haengseok SongDepartment of Biomedical Science, CHA University, Seongnam, Korea.
CHA University · KRKonkuk University · KRBaylor College of Medicine · USNational Institute of Environmental Health Sciences · US

Funding

Environmental Signaling in Reproduction and PregnancyZIAES103311 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DEMAYO, FRANCESCO · 2016 to 2025
$30.5M
National Research Foundation of Korea 2016R1C1B1015648National Research Foundation of Korea 2019R1A6A1A03032888National Research Foundation of Korea 2020R1A2C1004122National Research Foundation of Korea 2020R1A2C2005012
6 · The paper itself

Abstract

objectivesThe female reproductive tract comprises several different cell types. Using three representative Cre systems, we comparatively analysed the phenotypes of Dgcr8 conditional knockout (cKO) mice to understand the function of Dgcr8, involved in canonical microRNA biogenesis, in the female reproductive tract. MATERIALS AND

methodsDgcr8

resultDgcr8

conclusionsDgcr8 deficiency with different Cre systems induces overlapping but distinct phenotypes as well as the profiles of microRNAs and their target mRNAs in the female reproductive tract, suggesting the importance of selecting the appropriate Cre driver to investigate the genes of interest.

Indexed as

AnimalsFemaleIntegrasesMiceMice, KnockoutMicroRNAsOviductsReproductionRNA-Binding ProteinsUterusCre recombinaseDgcr8 protein, mouseIntegrasesMicroRNAsRNA-Binding ProteinsDgcr8Dgcr8 conditional knockout micefemale reproductive tractMicroRNAsmultiple Cre systemsPhenotypes

Identifiers

PMID33496365
PMCPMC7941225
OpenAlexW3121327763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.