ArticleEuropean heart journal2021
Temporal changes in total and hippocampal brain volume and cognitive function in patients with chronic heart failure-the COGNITION.MATTERS-HF cohort study.
Article in European heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Clinical and Imaging Markers of Cardiac Function and Brain Health: A Meta-Analysis of Community-Based Studies.Neurology · 2025Pooled it
- Pooled it
- Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure.Frontiers in cardiovascular medicine · 2021Pooled it
- Computerized Cognitive Training and 24-Month Mortality in Heart Failure.The Journal of cardiovascular nursingTrial
- Neurocardiology: Brain-Heart Interactions in the Heart.MedComm · 2026Review
- Longitudinal trajectories of neurodegenerative biomarkers in the blood of patients with chronic heart failure.ESC heart failure · 2026Article
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- Bidirectional brain-heart interactions in health and disease.Nature reviews. Neurology · 2026Review
- Advances in brain MRI for CAD-associated cognitive impairment with supplementary perspectives from traditional Chinese medicine.Frontiers in medicine · 2026Review
- Structural brain injury on magnetic resonance imaging in heart failure and identifying patients at high-risk.Cerebral circulation - cognition and behavior · 2026Article
- Myocardial Inflammation as Key Mediator of Heart-brain Interaction After Myocardial Ischemia/Infarction: Mechanistic Exploration of Post-Myocardial Infarction Cognitive Dysfunction.Current neuropharmacology · 2026Review
- Association between falls and dementia risk: Evidence from three cohort studies.Journal of translational internal medicine · 2025Article
- Prevalence and associated factors of cognitive frailty in older patients with lung cancer undergoing chemotherapy: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- The heart-brain axis: neurocognitive frailty in heart failure.Journal of neurology · 2025Review
- Loss of glymphatic homeostasis in heart failure.Brain : a journal of neurology · 2025Article
- Trajectory of Cognitive Function After Incident Heart Failure.Circulation. Heart failure · 2025Article
- Brain atrophy in heart failure patients following left ventricular assist device implantation or heart transplantation.JHLT open · 2025Article
- Investigation of gray matter volume in individuals with heart failure and preserved ejection fraction.Frontiers in aging neuroscience · 2025Article
- Remembering what did not happen: the role of hypnosis in memory recall and false memories formation.Frontiers in psychology · 2025Review
- Impact of cognitive impairment on heart failure prognosis: insights into central nervous system mechanism.EJNMMI research · 2024Article
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Authors and funding
17 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWe quantified the concurring dynamics affecting total and hippocampal brain volume and cognitive function in patients with chronic heart failure (HF) over a period of three years. METHODS AND
resultsA total of 148 patients with mild stable HF entered this monocentric prospective cohort study: mean age 64.5 (10.8) years; 16.2% female; 77% in New York Heart Association functional classes I-II; 128 and 105 patients attended follow-up visits after 1 and 3 years, respectively. The assessment included cardiological, neurological, psychological work-up, and brain magnetic resonance imaging. Total and regional brain volumes were quantified using an operator-independent fully automated approach and reported normalized to the mean estimated intracranial volume. At baseline, the mean hippocampal volume was ∼13% lower than expected. However, the 3-year progressive hippocampal volume loss was small: -62 mm3 [95% confidence interval (CI) -81 to -42, P < 0.0001). This corresponded to a relative change of -1.8% (95% CI -2.3 to -1.2), which was similar in magnitude as observed with physiological aging. Moreover, the load of white matter hypointensities increased within the limits of normal aging. Cognitive function during the 3-year observation period remained stable, with 'intensity of attention' as the only domain declining (LSmean -1.82 points, 95% CI -3.05 to -0.58, P = 0.004). After 3 years, performance in all domains of cognition remained associated with hippocampal volume (r ≥ 0.29).
conclusionIn patients with predominantly mild HF, the markedly reduced hippocampal volume observed at baseline was associated with impaired cognitive function, but no accelerated deterioration in cognition and brain atrophy became evident over a mid-term period of three years.
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