ArticleJournal of the American Heart Association2021
Reversion From Pre-Diabetes Mellitus to Normoglycemia and Risk of Cardiovascular Disease and All-Cause Mortality in a Chinese Population: A Prospective Cohort Study.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Interventions for Reversing Prediabetes: A Systematic Review and Meta-Analysis.American journal of preventive medicine · 2022 · on this mapPooled it
- Development and validation of a prediction model based on machine learning algorithms for predicting the risk of heart failure in middle-aged and older US people with prediabetes or diabetes.Clinical cardiology · 2023Trial
- A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals.Nutrients · 2022Trial
- Outcome of lifestyle intervention in relation to duration of pre-diabetes: the Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) study.BMJ open diabetes research & care · 2022Trial
- Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study.Nutrients · 2021Trial
- Article
- Risk of progression to type 2 diabetes or regression to normoglycaemia among Ghanaians with prediabetes living in Ghana and the Netherlands: The RODAM prospective study.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Article
- A predictive study of glycaemic reversal in Chinese individuals with prediabetes based on machine learning: a 5-year cohort study.Frontiers in endocrinology · 2026Article
- Impact of the longitudinal evolution of impaired fasting glucose on cardio-kidney-metabolic multimorbidity.Frontiers in endocrinology · 2026Article
- Association of PM2.5 exposure with 10-year atherosclerotic cardiovascular disease risk: a mediation analysis of blood and urinary biomarkers.Frontiers in public health · 2026Article
- Regression from prediabetes to normoglycaemia and the role of cardiometabolic risk factors on the subsequent risk of developing type 2 diabetes.Diabetologia · 2026Article
- Five-Year outcomes of a digitally delivered carbohydrate-reduced nutrition intervention for prediabetes: durability of diabetes prevention.Frontiers in nutrition · 2026Article
- Epidemiological features and prevalence patterns of prediabetes outcomes in an east coast Malaysian cohort: A retrospective cohort study.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2026Article
- Article
- Joint associations of pre-diabetes, pre-hypertension, and pre-dyslipidemia with cardiovascular and metabolic disease progression.Diabetology & metabolic syndrome · 2025Article
- The Impact of Tea Consumption on Prediabetes Regression and Progression: A Prospective Cohort Study.Nutrients · 2025Article
- Prognostic impact of prediabetes on long-term cardiovascular outcomes in patients under 35 with premature acute myocardial infarction.Diabetology & metabolic syndrome · 2025Article
- Nonlinear relationship between hepatic steatosis index and reversion to normal glucose regulation in Chinese adults with prediabetes.Scientific reports · 2025Article
- Association between the aspartate aminotransferase-to-alanine aminotransferase ratio and the reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background It is unclear whether reversion from pre-diabetes mellitus to normoglycemia reduces cardiovascular disease (CVD) and all-cause mortality risk in a Chinese population. We aimed to fill this research gap. Methods and Results The current study included 14 231 Chinese participants (mean age, 58.08 years) who were free from myocardial infarction and stroke at the time of survey participation (2006-2007 and 2008-2009). Participants were divided into 3 categories according to the 2-year changes in pre-diabetes mellitus, defined by fasting plasma glucose: those with progression to diabetes mellitus, those with reversion from pre-diabetes mellitus to normoglycemia, and those with persistent pre-diabetes mellitus. Cox proportional hazards models were used to calculate hazard ratios (HRs) and their 95% CIs for CVD and all-cause mortality. After a median follow-up period of 8.75 years, a total of 879 CVD events (including 180 myocardial infarction events and 713 stroke events) and 941 all-cause mortality events were recorded. After adjustment for confounding factors, reversion from pre-diabetes mellitus to normoglycemia was associated with decreased risks of CVD (HR, 0.78; 95% CI, 0.64-0.96), myocardial infarction (HR, 0.62; 95% CI, 0.40-0.97), stroke (HR, 0.79; 95% CI, 0.63-0.98), and all-cause mortality (HR, 0.82; 95% CI, 0.68-0.99) compared with progression to diabetes mellitus. Conclusions Reversion from fasting plasma glucose-defined pre-diabetes mellitus to normoglycemia was associated with a reduction in the future risk of CVD and all-cause mortality in a Chinese population. Registration URL: https://www.chictr.org; Unique identifier: ChiCTRTNC-11001489.
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