ArticleBioprocess and biosystems engineering2021
Isolation, identification and bioactivity analysis of an endophytic fungus isolated from Aloe vera collected from Asir desert, Saudi Arabia.
Article in Bioprocess and biosystems engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Phytochemical Profiling and Evaluation of Antibacterial, Anticancer, Anti-inflammatory, and Wound-Healing Activities of Endophytic Fungi Isolated From Atalantia racemosa.Chemistry & biodiversity · 2026Article
- Isolation, identification, and bioactivity evaluation of endophytic fungi from Ruta graveolens: insights into antimicrobial and antioxidant potential.Folia microbiologica · 2025Article
- Endophytic Bioactive Compounds for Wound Healing: A Review of Biological Activities and Therapeutic Potential.Microorganisms · 2025Review
- Bioactive Compounds From Saudi Arabian Fungi: A Systematic Review of Anticancer Potential.Clinical pharmacology : advances and applications · 2025Review
- First complete mitogenome of Massarineae and its contribution to phylogenetic implications in Pleosporales.Scientific reports · 2023Article
- Potential antibacterial and antioxidant inhibitory activities ofSaudi journal of biological sciences · 2023Article
- Bioactive Compounds Produced by Endophytic Microorganisms Associated with Bryophytes-The "Bryendophytes".Molecules (Basel, Switzerland) · 2023Review
- The ethnomedicinal evidences pertaining to traditional medicinal herbs used in the treatment of respiratory illnesses and disorders in Saudi Arabia: A review.Saudi journal of biological sciences · 2022Review
- Global regulatory factor VeA upregulates the production of antitumor substances in endophytic Fusarium solani.Antonie van Leeuwenhoek · 2022Article
- Medicinal plants used for dermatological disorders among the people of the kingdom of Saudi Arabia: A narrative review.Saudi journal of biological sciences · 2022Review
- Desert soil fungi isolated from Saudi Arabia: cultivable fungal community and biochemical production.Saudi journal of biological sciences · 2022Article
- Marine fungi showing multifunctional activity against human pathogenic microbes and cancer.PloS one · 2022Article
- Cloning and Functional Characterization of the Polyketide Synthases Based on Genome Mining ofFrontiers in microbiology · 2022Article
- Species identity and combinations differ in their overall benefits toFrontiers in plant science · 2022Article
- Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungusFrontiers in microbiology · 2022Article
- Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals.Biotechnology reports (Amsterdam, Netherlands) · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Endophytic fungi isolated from desert plants are among the less known organisms with potentially valuable applications. The bioactivities of an endophytic fungus isolated from Aloe vera, a plant found in central regions of Asir desert, Saudi Arabia. Based on primary phytochemical screening, an efficient isolate was selected and identified according to the sequence analysis of the internal spacer regions ITS1, ITS4 and the 5.8S region as Preussia africana belonging to the family Sporormiaceae. The crude extract of this fungus was evaluated for its bioactivities. Under static conditions, the crude extract at a concentration of 500 μg/mL had a strong 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging rate of 87%, whereas a higher concentration (100 μg/mL) had an astounding wound healing effect (42.6% at 48 h) when compared to positive control. Moreover, the crude extract with a concentration of 50 μg/mL was active against almost all cancer cell lines such as HeLa (cervical cancer), Hep G2 (liver cancer), MCF-7 (breast cancer), A549 (lung cancer), LN-229 (glioblastoma), A-431 (skin cancer), and kidney cell line (HEK 293T). The results suggest that the endophytic fungus P. africana from A. vera has wide therapeutic applications against severe disease conditions.
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