Evidence map›Paper›PMID 33495926›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

A simple strategy to reduce the salivary gland and kidney uptake of PSMA-targeting small molecule radiopharmaceuticals.

Teja Muralidhar Kalidindi, Sang-Gyu Lee, Katerina Jou, Goutam Chakraborty, Myrto Skafida, Scott T Tagawa, Neil H Bander, Heiko Schoder, Lisa Bodei, Neeta Pandit-Taskar and 4 more

Open access · greenAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

  1. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Effective treatment of human prostate carcinoma xenografts with Single-Dose PSMA-targeted [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Preclinical Evaluation of a Novel High-Affinity Radioligand [International journal of molecular sciences · 2023
    Article
  11. Preclinical Imaging of Prostate Cancer.Seminars in nuclear medicine · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Advances in PSMA theranostics.Translational oncology · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Teja Muralidhar KalidindiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, MSKCC Zuckerman Building, 417 E 68th St, New York, NY, 10065, USA.
Sang-Gyu LeeDepartment of Radiology, Memorial Sloan Kettering Cancer Center, MSKCC Zuckerman Building, 417 E 68th St, New York, NY, 10065, USA.
Katerina JouDepartment of Radiology, Memorial Sloan Kettering Cancer Center, MSKCC Zuckerman Building, 417 E 68th St, New York, NY, 10065, USA.
Goutam ChakrabortyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Myrto SkafidaDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Scott T TagawaDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA.
Neil H BanderDepartment of Urology, Weill Cornell Medicine, New York, NY, USA.
Heiko SchoderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, MSKCC Zuckerman Building, 417 E 68th St, New York, NY, 10065, USA.
Lisa BodeiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, MSKCC Zuckerman Building, 417 E 68th St, New York, NY, 10065, USA.
Neeta Pandit-TaskarDepartment of Radiology, Memorial Sloan Kettering Cancer Center, MSKCC Zuckerman Building, 417 E 68th St, New York, NY, 10065, USA.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, MSKCC Zuckerman Building, 417 E 68th St, New York, NY, 10065, USA.
Steven M LarsonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, MSKCC Zuckerman Building, 417 E 68th St, New York, NY, 10065, USA.
Joseph R OsborneDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA. jro7001@med.cornell.edu.
Naga Vara Kishore PillarsettyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, MSKCC Zuckerman Building, 417 E 68th St, New York, NY, 10065, USA. pillarsn@mskcc.org.ORCID http://orcid.org/0000-0002-1750-7436
Memorial Sloan Kettering Cancer Center · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
A new technique to make 68Ga-labeled pharmaceuticals widely available for clinical useR01CA207645 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI EASWARAMOORTHY, BALU, OSBORNE, JOSEPH REGINALD · 2016 to 2018
$1.7M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA207645NCI NIH HHS R35 CA232130
6 · The paper itself

Abstract

purposePeptide-based prostate-specific membrane antigen (PSMA) targeted radionuclide therapy (TRT) agent [

methodsGroups of athymic nude mice (n = 4) bearing PC3-PIP (PSMA+) tumor xenografts were administered with [

resultsBiodistribution studies at 1 h post-administration revealed that [

conclusionThe uptake of [

Indexed as

KidneyRadiopharmaceuticalsAnimalsAntigens, SurfaceGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingHumansMiceMice, NudeQuality of LifeSalivary GlandsTissue DistributionTumor Protein, Translationally-Controlled 1Antigens, SurfaceGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingRadiopharmaceuticalsTpt1 protein, mouseTumor Protein, Translationally-Controlled 1Dose reductionKidneysPSMA-617PSMA TRTSalivary glandsSpecific activity

Identifiers

PMID33495926
PMCPMC10134681
OpenAlexW3125449118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.