ArticleNeurocritical care2021
Cerebrovascular Autoregulation Monitoring in the Management of Adult Severe Traumatic Brain Injury: A Delphi Consensus of Clinicians.
Article in Neurocritical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- Monitoring of Cerebral Blood Flow Autoregulation after Cardiac Arrest.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Reliability and validity of the mean flow index (Mx) for assessing cerebral autoregulation in humans: A systematic review of the methodology.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Pooled it
- Cerebral Autoregulation in Non-Brain Injured Patients: A Systematic Review.Frontiers in neurology · 2021Pooled it
- Toward comprehensive multimodal neuromonitoring of surrogates of cerebral autoregulation in traumatic brain injury: insights from a hyperventilation protocol.Neurophotonics · 2026Article
- Multi-center pressure reactivity index temporal trajectories for predicting outcome in comatose subarachnoid hemorrhage patients.Neurosurgical review · 2026Article
- Detection of regional disparity in cerebrovascular reactivity using a custom whole brain functional near-infrared spectroscopy based mapping system: A prospective observational study.PLOS digital health · 2026Article
- ARIMA-based forecasting of cerebral physiologic signals in acute traumatic brain injury: a CAnadian high-resolution TBI (CAHR-TBI) cohort study.Intensive care medicine experimental · 2026Article
- Personalizing brain perfusion in traumatic brain injury.Critical care science · 2026Article
- Optimal cerebrovascular reactivity thresholds for the determination of individualized intracranial pressure thresholds in traumatic brain injury: a CAHR-TBI cohort study.Critical care (London, England) · 2025Article
- Management of intracranial hypertension with and without invasive intracranial pressure monitoring.World journal of critical care medicine · 2025Review
- Time-Domain Analysis of Low- and High-Frequency Near-Infrared Spectroscopy Sensor Technologies for Characterization of Cerebral Pressure-Flow and Oxygen Delivery Physiology: A Prospective Observational Study.Sensors (Basel, Switzerland) · 2025Observational
- Time-Series Autoregressive Models for Point and Interval Forecasting of Raw and Derived Commercial Near-Infrared Spectroscopy Measures: An Exploratory Cranial Trauma and Healthy Control Analysis.Bioengineering (Basel, Switzerland) · 2025Article
- Impaired Cerebral Autoregulation in Children.Pediatric neurology · 2025Review
- Leveraging Function Intersectionality and Multi-Modal Cerebrovascular Reactivity Measures for the Derivation of Individualized Intracranial Pressure Thresholds in Acute Traumatic Neural Injury.Bioengineering (Basel, Switzerland) · 2025Article
- Impact of Temporal Resolution on Autocorrelative Features of Cerebral Physiology from Invasive and Non-Invasive Sensors in Acute Traumatic Neural Injury: Insights from the CAHR-TBI Cohort.Sensors (Basel, Switzerland) · 2025Article
- Untangling discrepancies between cerebrovascular autoregulation correlation coefficients: An exploration of filters, coherence and power.Physiological reports · 2025Article
- Commercial NIRS May Not Detect Hemispheric Regional Disparity in Continuously Measured COx/COx-a: An Exploratory Healthy and Cranial Trauma Time-Series Analysis.Bioengineering (Basel, Switzerland) · 2025Article
- Understanding the Brain-Heart-Lung Triangle: Mission Impossible?Neurocritical care · 2025Article
- Continuous personalized cerebrovascular reactivity-based physiologic metrics in neurocritical care: a narrative review of the current landscape, limitations, and future directions.Frontiers in physiology · 2025Review
- Individualized autoregulation-guided arterial blood pressure management in neurocritical care.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 20 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral methods have been proposed to measure cerebrovascular autoregulation (CA) in traumatic brain injury (TBI), but the lack of a gold standard and the absence of prospective clinical data on risks, impact on care and outcomes of implementation of CA-guided management lead to uncertainty.
aimTo formulate statements using a Delphi consensus approach employing a group of expert clinicians, that reflect current knowledge of CA, aspects that can be implemented in TBI management and CA research priorities.
methodsA group of 25 international academic experts with clinical expertise in the management of adult severe TBI patients participated in this consensus process. Seventy-seven statements and multiple-choice questions were submitted to the group in two online surveys, followed by a face-to-face meeting and a third online survey. Participants received feedback on average scores and the rationale for resubmission or rephrasing of statements. Consensus on a statement was defined as agreement of more than 75% of participants.
resultsConsensus amongst participants was achieved on the importance of CA status in adult severe TBI pathophysiology, the dynamic non-binary nature of CA impairment, its association with outcome and the inadvisability of employing universal and absolute cerebral perfusion pressure targets. Consensus could not be reached on the accuracy, reliability and validation of any current CA assessment method. There was also no consensus on how to implement CA information in clinical management protocols, reflecting insufficient clinical evidence.
conclusionThe Delphi process resulted in 25 consensus statements addressing the pathophysiology of impaired CA, and its impact on cerebral perfusion pressure targets and outcome. A research agenda was proposed emphasizing the need for better validated CA assessment methods as well as the focused investigation of the application of CA-guided management in clinical care using prospective safety, feasibility and efficacy studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.