Evidence map›Paper›PMID 33495902›Full record

ArticleJournal of clinical immunology2021

Infectious Complications Predict Premature CD8

Junghee J Shin, Jason Catanzaro, Jennifer R Yonkof, Ottavia Delmonte, Keith Sacco, Min Sun Shin, Srikar Reddy, Paula J Whittington, Gary Soffer, Peter J Mustillo and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Junghee J ShinSection of Rheumatology, Allergy and Immunology, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.
Jason CatanzaroSection of Pulmonology, Allergy, Immunology and Sleep Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Jennifer R YonkofDivision of Allergy and Immunology, Nationwide Children's Hospital, Columbus, OH, 43212, USA.
Ottavia DelmonteLaboratory of Clinical Immunology and Microbiology, National Institution of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20893, USA.
Keith SaccoLaboratory of Clinical Immunology and Microbiology, National Institution of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20893, USA.
Min Sun ShinSection of Rheumatology, Allergy and Immunology, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.
Srikar ReddySection of Rheumatology, Allergy and Immunology, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.
Paula J WhittingtonSection of Rheumatology, Allergy and Immunology, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.
Gary SofferSection of Pulmonology, Allergy, Immunology and Sleep Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Peter J MustilloDivision of Allergy and Immunology, Nationwide Children's Hospital, Columbus, OH, 43212, USA.
Kathleen E SullivanDivision of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, National Institution of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20893, USA.
Roshini S AbrahamDivision of Allergy and Immunology, Nationwide Children's Hospital, Columbus, OH, 43212, USA.
Neil RombergDivision of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Insoo KangSection of Rheumatology, Allergy and Immunology, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA. Insoo.kang@yale.edu.ORCID 0000-0001-7483-1171
Yale University · USNational Institute of Allergy and Infectious Diseases · USNationwide Children's Hospital · USChildren's Hospital of Philadelphia · USKaiser Permanente · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Characterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2M
The Impact of Aging and HIV Infection on Immunologic and Transcriptomic Signatures of Influenza Vaccine ResponseR01AG055362 · NIA · YALE UNIVERSITY · PI KANG, INSOO, SHAW, ALBERT C · 2017 to 2021
$4.0M
Studying the impact of altered CD8+ T cell immunity in Alzheimer's diseaseR01AG056728 · NIA · YALE UNIVERSITY · PI KANG, INSOO · 2018 to 2022
$2.3M
BLOCKING AUTOANTIBODY SECRETION IN CVID PATIENTS WITH ITP BY IL-2 RESTORED TREGSK23AI115001 · NIAID · YALE UNIVERSITY · PI ROMBERG, NEIL DAVID · 2015 to 2019
$909k
Intramural NIH HHS ZIA AI001222NCATS NIH HHS UL1 TR001863NIAID NIH HHS K23 AI115001NIA NIH HHS R01 AG055362NIA NIH HHS R01 AG056728NIH HHS 1R01AG056728NIH HHS K23AI115001NIH HHS R01AG055362
6 · The paper itself

Abstract

purposeCD40 ligand (CD40L)-deficient patients display increased susceptibilities to infections that can be mitigated with effective prophylactic strategies including immunoglobulin G (IgG) replacement and prophylactic antibiotics. CD8

methodsPeripheral CD8

resultsThree patients (5, 28, and 34 years old) who were poorly adherent to immunoglobulin G replacement and Pneumocystis jirovecii pneumonia (PJP) prophylaxis and/or experienced multiple childhood pneumonias (patient group 1) had an expansion of effector memory CD8

conclusionsOur findings support that recurrent infections and non-adherence to prophylaxis promote early CD8

Indexed as

AdolescentAdultAge of OnsetBiomarkersCase-Control StudiesCD40 LigandCD8-Positive T-LymphocytesCellular SenescenceChild, PreschoolGenes, X-LinkedGenetic Association StudiesGenetic Predisposition to DiseaseHumansImmune System DiseasesImmunophenotypingInfectionsBiomarkersCD40 LigandReceptors, Antigen, T-CellCD8+ T-cell senescenceclass switching recombination defectcombined immunodeficiencyimmunoglobulin replacement therapyPneumocystis jirovecii pneumonia (PJP) prophylactic antibioticsX-linked CD40 ligand deficiency

Identifiers

PMID33495902
PMCPMC8329305
OpenAlexW3125728761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.