Evidence map›Paper›PMID 33495811›Full record

ArticleInternational journal of molecular medicine2021

Effects of Smad4 on the expression of caspase‑3 and Bcl‑2 in human gingival fibroblasts cultured on 3D PLGA scaffolds induced by compressive force.

Shuang Zhao, Lan Nan, Yao Wang, Liying Wei, Shuixue Mo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Multiple Cell Cultures for MRI Analysis.International journal of molecular sciences · 2022
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shuang ZhaoDepartment of Stomatology, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Lan NanDepartment of Stomatology, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Yao WangDepartment of Stomatology, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Liying WeiDepartment of Stomatology, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Shuixue MoDepartment of Stomatology, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Guangxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human gingival fibroblasts (HGFs) are the main cells that comprise gingival tissue, where they transfer mechanical signals under physiological and pathological conditions. The exact mechanism underlying gingival tissue reconstruction under compressive forces remains unclear. The present study aimed to explore the effects of Smad4, caspase‑3 and Bcl‑2 on the proliferation of HGFs induced by compressive force. HGFs were cultured on poly(lactide‑co‑glycolide) (PLGA) scaffolds under an optimal compressive force of 25 g/cm

Indexed as

Gene Expression RegulationAdolescentB-Cell Lymphoma 3 ProteinCaspase 3ChildCompressive StrengthFemaleFibroblastsGingivaHumansMalePolylactic Acid-Polyglycolic Acid CopolymerSmad4 ProteinTissue ScaffoldsB-Cell Lymphoma 3 ProteinBCL3 protein, humanCASP3 protein, humanCaspase 3Polylactic Acid-Polyglycolic Acid CopolymerSmad4 ProteinSMAD4 protein, humanBcl‑2caspase‑3compression pressurehuman gingival fibroblastspoly(lactide‑co‑glycolide)Smad4

Identifiers

PMID33495811
PMCPMC7846422
OpenAlexW3121988728

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.