ArticleNature neuroscience2021
Targeted photostimulation uncovers circuit motifs supporting short-term memory.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Reusable modular architecture enables flexible cognitive operations in the mouse brain and artificial recurrent networks.Nature neuroscience · 2026Article
- Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Probing inter-areal computations with a two-photon holographic mesoscope.Nature neuroscience · 2026Article
- The Importance of Synchrony in the Neural Control of Movement.bioRxiv : the preprint server for biology · 2026Article
- Tunable Bessel beam two-photon fluorescence microscopy for high-speed volumetric imaging of brain dynamics.eLife · 2026Article
- Tuft dendrite spikes are accompanied by selective input from distinct functional networks.bioRxiv : the preprint server for biology · 2026Article
- Single-Cell Perturbations Reveal Selective Modulation of Causal Connectivity During Decision-Making.bioRxiv : the preprint server for biology · 2026Article
- Functional reorganization of motor cortex connectivity during learning.bioRxiv : the preprint server for biology · 2026Article
- Control of cortical population activity with patterned microstimulation.bioRxiv : the preprint server for biology · 2026Article
- Tunable Bessel beam two-photon fluorescence microscopy for high-speed volumetric imaging of brain dynamics.bioRxiv : the preprint server for biology · 2026Article
- Brain-computer interfaces as a causal probe for scientific inquiry.Trends in cognitive sciences · 2026Review
- Brain-wide analysis reveals movement encoding structured across and within brain areas.Nature neuroscience · 2026Article
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- Desensitization of opsin responses during all-optical interrogation depends on imaging parameters.Neurophotonics · 2026Article
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- Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification.bioRxiv : the preprint server for biology · 2025Article
- A real-time all-optical interface for dynamic perturbation of neural activity during behavior.Cell reports methods · 2025Article
- Network dynamics underlying activity-timescale differences between cortical regions.bioRxiv : the preprint server for biology · 2025Article
- Reusable modular architecture enables flexible cognitive operations.Research square · 2025Article
- Rapid rebalancing of co-tuned ensemble activity in the auditory cortex.bioRxiv : the preprint server for biology · 2025Article
6 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Short-term memory is associated with persistent neural activity that is maintained by positive feedback between neurons. To explore the neural circuit motifs that produce memory-related persistent activity, we measured coupling between functionally characterized motor cortex neurons in mice performing a memory-guided response task. Targeted two-photon photostimulation of small (<10) groups of neurons produced sparse calcium responses in coupled neurons over approximately 100 μm. Neurons with similar task-related selectivity were preferentially coupled. Photostimulation of different groups of neurons modulated activity in different subpopulations of coupled neurons. Responses of stimulated and coupled neurons persisted for seconds, far outlasting the duration of the photostimuli. Photostimuli produced behavioral biases that were predictable based on the selectivity of the perturbed neuronal population, even though photostimulation preceded the behavioral response by seconds. Our results suggest that memory-related neural circuits contain intercalated, recurrently connected modules, which can independently maintain selective persistent activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.