ArticleNature microbiology2021
Genome-resolved metagenomics reveals site-specific diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems.
Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.
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Who cites it
136 citing papers in PubMed.
- Microbial ecology of shallow groundwater ecosystems.Nature reviews. Microbiology · 2026Review
- Groundwater microbial communities across the terrestrial subsurface.Nature microbiology · 2026Review
- Magnetotaxis in an anaerobic ciliate via tripartite syntrophy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mobile genetic elements shape microbial diversity and functions in thawing permafrost soils.Nature microbiology · 2026Article
- Multi-Year Biofilm Formation on Granitic Surfaces Reveals Dynamic Microbial Communities in Fennoscandian Shield Deep Groundwaters.Microbial ecology · 2026Article
- A Novel Pilus System in Candidate Phyla Radiation Bacteria.bioRxiv : the preprint server for biology · 2026Article
- Divergent evolution of the PRPS enzymes across the tree of life.bioRxiv : the preprint server for biology · 2026Article
- Ultrasmall oral Saccharibacteria modulate gingival immunoactivation through type IV pili and TLR2-dependent endocytosis.Nature communications · 2026Article
- Group I introns in tRNA genes of Patescibacteria.mSystems · 2026Article
- Comparative Genomic Insights into MatE Transporter Diversity and Habitat Adaptation of Archaea.Microorganisms · 2026Article
- Cross-feeding options define genome evolution and community assembly of deep groundwater microbiome.Environmental microbiome · 2026Article
- Metagenomics reveals potential interactions between Patescibacteriota and their phages in groundwater ecosystems.mSystems · 2026Article
- Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Horizontal gene transfer and gene loss drove the divergent evolution of host dependency in Micrarchaeota.National science review · 2026Article
- Diversity and ecological roles of hidden viral players in groundwater microbiomes.Nature communications · 2026Article
- Prokaryotic assemblages recovered by sedimentary DNA record natural and human-driven disturbances over the past 13 500 years in a cultural landscape.The ISME journal · 2026Article
- Groundwater microbial community structure under contrasting hydrological conditions in a sulfate-rich karst aquifer.Frontiers in microbiology · 2026Article
- Current Understanding of Taxonomy and Ecology of the Phylum Minisyncoccota.Microbes and environments · 2026Review
- Revised 16S rRNA V4 hypervariable region targeting primers enhance detection of Patescibacteria and other lineages across diverse environments.ISME communications · 2026Article
- Summer drought impacts micropredator abundance and microbial food web structure in a rewetted fen peatland.ISME communications · 2026Article
76 more citing papers are in PubMed but not listed here.
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7 authors.
Funding
Abstract
Candidate phyla radiation (CPR) bacteria and DPANN archaea are unisolated, small-celled symbionts that are often detected in groundwater. The effects of groundwater geochemistry on the abundance, distribution, taxonomic diversity and host association of CPR bacteria and DPANN archaea has not been studied. Here, we performed genome-resolved metagenomic analysis of one agricultural and seven pristine groundwater microbial communities and recovered 746 CPR and DPANN genomes in total. The pristine sites, which serve as local sources of drinking water, contained up to 31% CPR bacteria and 4% DPANN archaea. We observed little species-level overlap of metagenome-assembled genomes (MAGs) across the groundwater sites, indicating that CPR and DPANN communities may be differentiated according to physicochemical conditions and host populations. Cryogenic transmission electron microscopy imaging and genomic analyses enabled us to identify CPR and DPANN lineages that reproducibly attach to host cells and showed that the growth of CPR bacteria seems to be stimulated by attachment to host-cell surfaces. Our analysis reveals site-specific diversity of CPR bacteria and DPANN archaea that coexist with diverse hosts in groundwater aquifers. Given that CPR and DPANN organisms have been identified in human microbiomes and their presence is correlated with diseases such as periodontitis, our findings are relevant to considerations of drinking water quality and human health.
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