ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021
Accelerated brain aging predicts impulsivity and symptom severity in depression.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- BrainAGE, brain health, and mental disorders: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Trial
- Accelerated Brain Aging in Adults With Major Depressive Disorder Predicts Poorer Outcome With Sertraline: Findings From the EMBARC Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Trial
- Generalizable and explainable deep learning for brain MRI: a multi-cohort evaluation of 3D architectures for age and sex prediction.Brain informatics · 2026Article
- Personalized functional topography-based multisite brain age prediction modeling reveals divergent neurodevelopment in major depression.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Brain Age Gap as a Predictor of Alcohol Initiation in Adolescence.bioRxiv : the preprint server for biology · 2026Article
- Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study.BMC medicine · 2026Article
- Age-Related Differences and Effects of Internalizing Symptoms on Aperiodic Neural Activity in Adolescents.Psychophysiology · 2026Article
- Neuroanatomical features reveal accelerated brain age in alcohol use disorder.bioRxiv : the preprint server for biology · 2025Article
- Alterations in aperiodic neural activity associated with major depressive disorder.Nature. Mental health · 2025Article
- Identifying key brain pathology in bipolar and unipolar depression using a region-specific brain aging trajectories approach: Insights from the Taiwan Aging and Mental Illness Cohort.Psychological medicine · 2025Article
- Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study.Translational psychiatry · 2025Article
- Lifestyle, Early-life, and Genetic Health Risk Factors Underlying the Brain Age Gap: A Mega-Analysis Across 3,934 Individuals from the ENIGMA MDD Consortium.bioRxiv : the preprint server for biology · 2025Article
- Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18.Scientific reports · 2025Article
- Examining anterior prefrontal cortex resting-state functional connectivity patterns associated with depressive symptoms in chronic moderate-to-severe traumatic brain injury.Frontiers in neurology · 2025Article
- Dimensional and Categorical Solutions to Parsing Depression Heterogeneity in a Large Single-Site Sample.Biological psychiatry · 2024Article
- Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Sex differences in biological aging and the association with clinical measures in older adults.GeroScience · 2024Article
- The Role of Puberty and Sex on Brain Structure in Adolescents With Anxiety Following Concussion.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Multiple structural and functional neuroimaging measures vary over the course of the lifespan and can be used to predict chronological age. Accelerated brain aging, as quantified by deviations in the MRI-based predicted age with respect to chronological age, is associated with risk for neurodegenerative conditions, bipolar disorder, and mortality. Whether age-related changes in resting-state functional connectivity are accelerated in major depressive disorder (MDD) is unknown, and, if so, it is unclear if these changes contribute to specific cognitive weaknesses that often occur in MDD. Here, we delineated age-related functional connectivity changes in a large sample of normal control subjects and tested whether brain aging is accelerated in MDD. Furthermore, we tested whether accelerated brain aging predicts individual differences in cognitive function. We trained a support vector regression model predicting age using resting-state functional connectivity in 710 healthy adults aged 18-89. We applied this model trained on normal aging subjects to a sample of actively depressed MDD participants (n = 109). The difference between predicted brain age and chronological age was 2.11 years greater (p = 0.015) in MDD patients compared to control participants. An older MDD brain age was significantly associated with increased impulsivity and, in males, increased depressive severity. Unexpectedly, accelerated brain aging was also associated with increased placebo response in a sham-controlled trial of high-frequency repetitive transcranial magnetic stimulation targeting the dorsomedial prefrontal cortex. Our results indicate that MDD is associated with accelerated brain aging, and that accelerated aging is selectively associated with greater impulsivity and depression severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.