Evidence map›Paper›PMID 33495542›Full record

ArticleCommunications biology2021

Genome-wide study of a Neolithic Wartberg grave community reveals distinct HLA variation and hunter-gatherer ancestry.

Alexander Immel, Federica Pierini, Christoph Rinne, John Meadows, Rodrigo Barquera, András Szolek, Julian Susat, Lisa Böhme, Janina Dose, Joanna Bonczarowska and 14 more

Abstract readHistorical Article
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Alexander ImmelInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.
Federica PieriniResearch Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, August-Thienemann-Strasse 2, 24306, Plön, Germany.
Christoph RinneInstitute of Pre- and Protohistoric Archaeology, Kiel University, Johanna-Mestorf-Strasse 2-6, 24118, Kiel, Germany.
John MeadowsLeibniz Laboratory for AMS Dating and Isotope Research, Kiel University, Max-Eyth-Strasse 11-13, 24118, Kiel, Germany.ORCID 0000-0002-4346-5591
Rodrigo BarqueraMax Planck Institute for the Science of Human History, Khalaische Strasse 10, 07745, Jena, Germany.ORCID 0000-0003-0518-4518
András SzolekApplied Bioinformatics, Department for Computer Science, University of Tübingen, Sand 14, 72076, Tübingen, Germany.ORCID 0000-0003-4758-7817
Julian SusatInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.
Lisa BöhmeInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.
Janina DoseInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.
Joanna BonczarowskaInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.
Clara DrummerInstitute of Pre- and Protohistoric Archaeology, Kiel University, Johanna-Mestorf-Strasse 2-6, 24118, Kiel, Germany.
Katharina FuchsInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.
David EllinghausInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.ORCID 0000-0002-4332-6110
Jan Christian KässensInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.
Martin FurholtDepartment of Archaeology, Conservation and History, University of Oslo, Blindernveien 11, 0371, Oslo, Norway.
Oliver KohlbacherApplied Bioinformatics, Department for Computer Science, University of Tübingen, Sand 14, 72076, Tübingen, Germany.ORCID 0000-0003-1739-4598
Sabine Schade-LindigLandesamt für Denkmalpflege Hessen, hessenARCHÄOLOGIE, Schloss Biebrich, 65203, Wiesbaden, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.
Stefan SchreiberInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.
Johannes KrauseMax Planck Institute for the Science of Human History, Khalaische Strasse 10, 07745, Jena, Germany.ORCID 0000-0001-9144-3920
Johannes MüllerInstitute of Pre- and Protohistoric Archaeology, Kiel University, Johanna-Mestorf-Strasse 2-6, 24118, Kiel, Germany.
Tobias L LenzResearch Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, August-Thienemann-Strasse 2, 24306, Plön, Germany.ORCID 0000-0002-7203-0044
Almut NebelInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.
Ben Krause-KyoraInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany. b.krause-kyora@ikmb.uni-kiel.de.ORCID 0000-0001-9435-2872

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Wartberg culture (WBC, 3500-2800 BCE) dates to the Late Neolithic period, a time of important demographic and cultural transformations in western Europe. We performed genome-wide analyses of 42 individuals who were interred in a WBC collective burial in Niedertiefenbach, Germany (3300-3200 cal. BCE). The results showed that the farming population of Niedertiefenbach carried a surprisingly large hunter-gatherer ancestry component (34-58%). This component was most likely introduced during the cultural transformation that led to the WBC. In addition, the Niedertiefenbach individuals exhibited a distinct human leukocyte antigen gene pool, possibly reflecting an immune response that was geared towards detecting viral infections.

Indexed as

AgricultureAnimalsArchaeologyDNA, AncientEuropeEvolution, MolecularFeeding BehaviorGenetics, PopulationGenetic VariationGenome, HumanGenome-Wide Association StudyGermanyHistory, AncientHLA AntigensHuman MigrationHumansDNA, AncientHLA Antigens

Identifiers

PMID33495542
PMCPMC7835224

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.