Micropatterning biomineralization with immobilized mother of pearl proteins.

Kristopher A White, Vincent J Cali, Ronke M Olabisi

Open access · goldAbstract read

In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 99% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Trabecular-bone mimicking osteoconductive collagen scaffolds: an optimized 3D printing approach using freeform reversible embedding of suspended hydrogels.3D printing in medicine · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kristopher A WhiteDepartment of Biomedical Engineering, University of California-Irvine, Irvine, CA, USA.

Vincent J CaliDepartment of Anatomy and Physiology, Queens College, City University of New York, Bayside, NY, USA.

Ronke M OlabisiDepartment of Biomedical Engineering, University of California-Irvine, Irvine, CA, USA. ronke.olabisi@uci.edu.

University of California, Irvine · USQueens College, CUNY · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In response to the drawbacks of autograft donor-site morbidity and bone morphogenetic protein type 2 (BMP2) carcinogenesis and ectopic bone formation, there has been an increased research focus towards developing alternatives capable of achieving spatial control over bone formation. Here we show for the first time both osteogenic differentiation and mineralization (from solution or mediated by cells) occurring within predetermined microscopic patterns. Our results revealed that both PEGylated BMP2 and nacre proteins induced stem cell osteodifferentiation in microscopic patterns when these proteins were covalently bonded in patterns onto polyethylene glycol diacrylate (PEGDA) hydrogel substrates; however, only nacre proteins induced mineralization localized to the micropatterns. These findings have broad implications on the design and development of orthopedic biomaterials and drug delivery.

Indexed as

BiomineralizationMicrotechnologyAlkaline PhosphataseAnimalsBone and BonesCell LineHydrogelsImmobilized ProteinsMiceMicrospheresNacreOsteogenesisOstreidaePolyethylene GlycolsAlkaline PhosphataseHydrogelsImmobilized ProteinsNacrepoly(ethylene glycol)diacrylatePolyethylene Glycols

Identifiers

PMID33495508

DOI10.1038/s41598-021-81534-8

PMCPMC7835238

OpenAlexW3123734809

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.