SynthesisNature communications2021
Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.
Erratum issuedOpen access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
6.0field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis.Molecular psychiatry · 2022Pooled it
- Can polygenic risk scores help identify pediatric bipolar spectrum and related disorders?: A systematic review.Psychiatry research · 2021Pooled it
- Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq.bioRxiv : the preprint server for biology · 2026Article
- Common and rare genetic variants explain distinct diagnostic variance in pediatric attention deficit hyperactivity disorder.Genetics in medicine : official journal of the American College of Medical Genetics · 2025Article
- Exploring Mitochondrial DNA Copy Number in Italian Children with ADHD: Implications for Neurobiological Mechanisms.Diseases (Basel, Switzerland) · 2025Article
- Machine Learning in Adolescent Mental Health: Advanced Comorbidity Analysis and Text Mining Insights.Healthcare (Basel, Switzerland) · 2025Article
- Effect of Parental-Child Age Gaps and Skipped-Generation Families on Comorbidities Related to Attention Deficit Hyperactivity Disorder: A Population-Based Case-Control Study.Children (Basel, Switzerland) · 2025Article
- Association between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences.European child & adolescent psychiatry · 2025Article
- Not just old wine in new bottles: Polygenic liability for ADHD is associated with electrophysiological affective-motivational processing beyond anxiety, depression, and ODD.Translational psychiatry · 2025Article
- The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.The EMBO journal · 2025Article
- Generalized genetic liability to substance use disorders.The Journal of clinical investigation · 2024Review
- Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood.Biological psychiatry global open science · 2024Article
- Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes.Neuroscience and biobehavioral reviews · 2023Review
- Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort.Journal of neurodevelopmental disorders · 2023Article
- A missense mutation inScience advances · 2023Article
- Parasitic infections as potential risk factors for attention deficit hyperactivity disorder (ADHD) in children.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- Editorial: Advancements and challenges in developmental psychopathology and mental health.Frontiers in child and adolescent psychiatry · 2023Article
- The pleiotropic contribution of genes in dopaminergic and serotonergic pathways to addiction and related behavioral traits.Frontiers in psychiatry · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
21 authors at 20 institutions in 16 countries.
Ditte DemontisThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark. ditte@biomed.au.dk.ORCID http://orcid.org/0000-0001-9124-2766
Raymond K WaltersAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8422-6530
Veera M RajagopalThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-5236-168X
Irwin D WaldmanDepartment of Psychology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6862-1837
Jakob GroveThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-2284-5744
Thomas D AlsThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-2963-1928
Søren DalsgaardNational Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-4659-0969
Marta RibasésPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.ORCID http://orcid.org/0000-0003-1039-1116
Jonas Bybjerg-GrauholmThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-1705-4008
Maria Bækvad-HansenThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Thomas WergeThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-1829-0766
Merete NordentoftThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Ole MorsThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Preben Bo MortensenThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
ADHD Working Group of the Psychiatric Genomics Consortium (PGC)
Bru CormandDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Catalonia, Spain.
David M HougaardThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-5928-3517
Benjamin M NealeAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1513-6077
Barbara FrankeDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-4375-6572
Stephen V FaraoneDepartments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. sfaraone@childpsychresearch.org.
Anders D BørglumThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark. anders@biomed.au.dk.ORCID http://orcid.org/0000-0001-8627-7219
Aarhus University · DKHeidelberg University · DECardiff University · GBDouglas Mental Health University Institute · CARadboud University Nijmegen · NLStatens Serum Institut · DKUniversidade Federal do Rio Grande do Sul · BRUniversitat Autònoma de Barcelona · ESUniversity of Toronto · CAVall d'Hebron Hospital Universitari · ESBroad Institute · USHarvard University · USMonash University · AUNorwegian Institute of Public Health · NOQIMR Berghofer Medical Research Institute · AUSUNY Upstate Medical University · USUniversity Hospital Mútua de Terrassa · ESUniversity of Copenhagen · DKUniversity of Duisburg-Essen · DEAarhus University Hospital · DK
Funding
2/7 Psychiatric Genomics Consortium: Finding Actionable VariationU01MH109539 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2016 to 2020
$4.7M5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9MAir-pollution risk for Autism and ADHD - cross-disorder insights and genetic liabilityR01ES026993 · NIEHS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI KALKBRENNER, AMY E, SCHENDEL, DIANA · 2017 to 2021
$2.4MMedical Research Council G0300189NIEHS NIH HHS R01 ES026993NIMH NIH HHS U01 MH109514NIMH NIH HHS U01 MH109539
Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10
Indexed as
Polymorphism, Single NucleotideAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityChildChinaCohort StudiesComorbidityEuropeFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMultifactorial InheritanceRisk Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.