ArticleProceedings of the National Academy of Sciences of the United States of America2021
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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88citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
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Who cites it
88 citing papers in PubMed, 138 citations in OpenAlex.
- Sialic acidOncoimmunology · 2026Article
- Antibody-lectin chimeras for glyco-immune checkpoint blockade.Nature biotechnology · 2026Article
- From Glycocode to Precision Oncology: Therapeutic Strategies Targeting Aberrant O-GalNAc Glycosylation in Cancer.Chemical reviews · 2026Review
- Rapid discovery of cell-surface glycosylation regulators using a lectin-based magnetic CRISPR screen.Cell reports methods · 2026Article
- Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing.Nature communications · 2026Article
- Immune implications and therapeutic opportunities of tumor glycosylation.Nature cancer · 2026Review
- CRISPR activation screens identify core protein-dependent regulation of heparan sulfate sulfation and ligand specificity.bioRxiv : the preprint server for biology · 2026Article
- Sialic Acids in Kidney Disease: Immune Regulation, Complement Activation and Glomerular Injury.Antioxidants (Basel, Switzerland) · 2026Review
- Glycan atlassing enables functional tracing of cell state.Nature nanotechnology · 2026Article
- CRISPR activation screens map the genomic landscape of cancer glycome remodeling.Cell genomics · 2026Article
- Revealing cancer glycome drivers using CRISPR activation screens.Cell genomics · 2026Article
- Sialic acids modulate immune responses in cancer: Therapeutic opportunities.The Journal of biological chemistry · 2026Review
- EHD4 and ASAP2 are critical negative regulators of the claudin-5-based endothelial barrier.The FEBS journal · 2026Article
- Article
- Writers and readers of sialylation in immunoregulation in cancer.The Journal of biological chemistry · 2026Review
- Approaches to deorphanize secretome: Classical, computational, and next generation strategies to reveal ligand-receptor networks.EXO : beyond the cell · 2026Article
- Immunomodulation by glycosylation: bridging glycobiology to adaptive immunity and therapeutic innovation.Frontiers in immunology · 2026Review
- Siglec-7 inhibits TLR3-induced pro-inflammatory cytokine production from human monocytes and macrophages.Frontiers in immunology · 2026Article
- An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function.Science advances · 2025Article
- Mapping the placental galectin-3 interactome identifies CD9 and ITGB1 as functional glycoprotein counterreceptors during syncytialization.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Simon WisnovskyDepartment of Chemistry & Stanford ChEM-H, Stanford University, Stanford, CA 94305.ORCID 0000-0003-4010-4309
Leonhard MöcklDepartment of Chemistry & Stanford ChEM-H, Stanford University, Stanford, CA 94305.ORCID 0000-0003-1387-886X
Stacy A MalakerDepartment of Chemistry & Stanford ChEM-H, Stanford University, Stanford, CA 94305.ORCID 0000-0003-2382-5067
Kayvon PedramDepartment of Chemistry & Stanford ChEM-H, Stanford University, Stanford, CA 94305.ORCID 0000-0001-8365-1826
Gaelen T HessDepartment of Genetics, Stanford University, Stanford, CA 94305.
Nicholas M RileyDepartment of Chemistry & Stanford ChEM-H, Stanford University, Stanford, CA 94305.ORCID 0000-0002-1536-2966
Melissa A GrayDepartment of Chemistry & Stanford ChEM-H, Stanford University, Stanford, CA 94305.
Benjamin A H SmithDepartment of Chemistry & Stanford ChEM-H, Stanford University, Stanford, CA 94305.ORCID 0000-0001-8802-416X
Michael C BassikDepartment of Genetics, Stanford University, Stanford, CA 94305.
W E MoernerDepartment of Chemistry & Stanford ChEM-H, Stanford University, Stanford, CA 94305.ORCID 0000-0002-2830-209X
Carolyn R BertozziDepartment of Chemistry & Stanford ChEM-H, Stanford University, Stanford, CA 94305; bertozzi@stanford.edu.ORCID 0000-0003-4482-2754
Stanford University · USHoward Hughes Medical Institute · USMax Planck Institute for the Science of Light · DE
Funding
Single-Molecule Imaging for Cell Biology and Super-Resolution MicroscopyR35GM118067 · NIGMS · STANFORD UNIVERSITY · PI MOERNER, WILLIAM E · 2016 to 2025
$6.2MNational Glycoscience Resource- CCRC Service and Training - NGlycoR@CCRCR24GM137782 · NIGMS · UNIVERSITY OF GEORGIA · PI Parastoo Azadi · 2020 to 2026
$5.2MTargeting the Cancer GlycocalyxR01CA227942 · NCI · STANFORD UNIVERSITY · PI Carolyn Bertozzi · 2019 to 2026
$3.6MGlycosylation and Immune Evasion in Urologic TumorsU01CA226051 · NCI · STANFORD UNIVERSITY · PI BERTOZZI, CAROLYN, BROOKS, JAMES D. · 2019 to 2023
$3.0MStanford Chem-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM120007 · NIGMS · STANFORD UNIVERSITY · PI BERTOZZI, CAROLYN · 2016 to 2020
$1.2MOrbitrap Fusion Tribrid Mass SpectrometerS10OD018530 · OD · UNIVERSITY OF GEORGIA · PI AZADI, PARASTOO · 2014 to 2014
$750kUniting Mass Spectrometry and Glycoscience to Investigate Cancer BiologyK00CA212454 · NCI · STANFORD UNIVERSITY · PI RILEY, NICHOLAS M · 2018 to 2021
$331kMyc promoted changes to the glycocalyx in leukemiaF30CA232541 · NCI · STANFORD UNIVERSITY · PI SMITH, BENJAMIN ARTHUR HUMPHERS · 2019 to 2021
$130kAn enzymatic approach to study cancer-associated cell-surface glycoproteins: exploration of mucin-degrading bacterial metalloproteasesF32GM126663 · NIGMS · STANFORD UNIVERSITY · PI MALAKER, STACY ALYSE · 2017 to 2019
$125kCIHRNCI NIH HHS F30 CA232541NCI NIH HHS K00 CA212454NCI NIH HHS R01 CA227942NCI NIH HHS U01 CA226051NIGMS NIH HHS F32 GM126663NIGMS NIH HHS R24 GM137782NIGMS NIH HHS R35 GM118067NIGMS NIH HHS T32 GM120007NIH HHS S10 OD018530
Abstract
PubMed holds no abstract for this paper.
Indexed as
Genome, HumanAmino Acid MotifsAntigens, Differentiation, MyelomonocyticCell Line, TumorCell MembraneClustered Regularly Interspaced Short Palindromic RepeatsGlycopeptidesHumansImmunological SynapsesKiller Cells, NaturalLectinsLeukosialinLigandsPolysaccharidesProtein BindingAntigens, Differentiation, MyelomonocyticGlycopeptidesLectinsLeukosialinLigandsPolysaccharidesSIGLEC7 protein, humanCRISPR ScreeningGlycobiologyTumor Immunology
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.