Evidence map›Paper›PMID 33495321›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

DNA methylation-linked chromatin accessibility affects genomic architecture in

Zhenhui Zhong, Suhua Feng, Sascha H Duttke, Magdalena E Potok, Yiwei Zhang, Javier Gallego-Bartolomé, Wanlu Liu, Steven E Jacobsen

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
42.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 147 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Haplotype-Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Zhenhui ZhongDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.ORCID 0000-0002-8438-0375
Suhua FengDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Sascha H DuttkeDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.
Magdalena E PotokDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Yiwei ZhangDepartment of Orthopedic, Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310029, China.ORCID 0000-0001-7432-425X
Javier Gallego-BartoloméDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Wanlu LiuDepartment of Orthopedic, Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310029, China; wanluliu@intl.zju.edu.cn jacobsen@ucla.edu.ORCID 0000-0001-5963-2908
Steven E JacobsenDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095; wanluliu@intl.zju.edu.cn jacobsen@ucla.edu.
University of California, Los Angeles · USSecond Affiliated Hospital of Zhejiang University · CNHoward Hughes Medical Institute · USUniversity of California San Diego · US

Funding

Epigenetic gene regulation in ArabidopsisR35GM130272 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JACOBSEN, STEVEN E · 2019 to 2023
$1.6M
Exploiting Natural Genetic and Organismic Variation to Identify the DNA Motifs Regulating TranscriptionR00GM135515 · NIGMS · WASHINGTON STATE UNIVERSITY · PI DUTTKE, SASCHA H. · 2022 to 2024
$747k
Exploiting Natural Genetic and Organismic Variation to Identify the DNA Motifs Regulating TranscriptionK99GM135515 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DUTTKE, SASCHA H. · 2020 to 2021
$200k
NIGMS NIH HHS K99 GM135515NIGMS NIH HHS R00 GM135515NIGMS NIH HHS R35 GM130272
6 · The paper itself

Abstract

DNA methylation is a major epigenetic modification found across species and has a profound impact on many biological processes. However, its influence on chromatin accessibility and higher-order genome organization remains unclear, particularly in plants. Here, we present genome-wide chromatin accessibility profiles of 18

Indexed as

Genome, PlantArabidopsisChromatinDNA MethylationMutationTranscription, GeneticChromatinchromatin accessibilityDNA methylationepigenetics

Identifiers

PMID33495321
PMCPMC7865151
OpenAlexW3122921488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.