Evidence map›Paper›PMID 33495310›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2021

Imaging Tumor-Infiltrating Lymphocytes in Brain Tumors with [

Veronica L Nagle, Kelly E Henry, Charli Ann J Hertz, Maya S Graham, Carl Campos, Luis F Parada, Neeta Pandit-Taskar, Andrea Schietinger, Ingo K Mellinghoff, Jason S Lewis

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Granzyme B PET Imaging Reveals LgmnAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  8. Imaging Immunotherapy.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  9. Reengineered Anti-CD4 Cys-diabody Variants forMolecular imaging and biology · 2025
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  10. Review
  11. Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2025
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  12. Human dose-escalation study of PET imaging CD8European journal of nuclear medicine and molecular imaging · 2025
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  13. Review
  14. Review
  15. Article
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  17. [Theranostics · 2024
    Article
  18. Review
  19. Development ofChemical communications (Cambridge, England) · 2023
    Article
  20. Phenomic Imaging.Phenomics (Cham, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Veronica L NagleDepartment of Pharmacology, Weill Cornell Medical College, New York, New York.
Kelly E HenryDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-8492-9364
Charli Ann J HertzHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Maya S GrahamBrain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-4748-974X
Carl CamposHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Luis F ParadaBrain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York.
Neeta Pandit-TaskarDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-1551-2036
Andrea SchietingerImmunology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Ingo K MellinghoffDepartment of Pharmacology, Weill Cornell Medical College, New York, New York. lewisj2@mskcc.org mellingi@mskcc.org.ORCID 0000-0002-4347-8149
Jason S LewisDepartment of Pharmacology, Weill Cornell Medical College, New York, New York. lewisj2@mskcc.org mellingi@mskcc.org.ORCID 0000-0001-7065-4534
Memorial Sloan Kettering Cancer Center · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Isolation, characterization and translational development of glioma stem cellsR35CA210100 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PARADA, LUIS FERNANDO · 2017 to 2023
$7.4M
CLINICAL SCHOLARS BIOMEDICAL RESEARCH TRAINING PROGRAMT32CA009512 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Ping Chi · 1985 to 2026
$6.3M
Molecular Mechanisms of Drug Resistance in Primary Brain TumorsR35NS105109 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI MELLINGHOFF, INGO K · 2018 to 2025
$4.7M
Predoctoral Training in Pharmacological SciencesT32GM073546 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GROSS, STEVEN S · 2006 to 2020
$3.1M
Horizontal Bore 9.4T Magnet for MRIS10OD023669 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI KOUTCHER, JASON ARTHUR · 2017 to 2017
$600k
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA210100NCI NIH HHS R35 CA232130NCI NIH HHS T32 CA009512NIGMS NIH HHS T32 GM073546NIH HHS S10 OD023669NINDS NIH HHS R35 NS105109
6 · The paper itself

Abstract

purposeGlioblastoma (GBM) is the most common malignant brain tumor in adults. Various immunotherapeutic approaches to improve patient survival are being developed, but the molecular mechanisms of immunotherapy resistance are currently unknown. Here, we explored the ability of a humanized radiolabeled CD8-targeted minibody to noninvasively quantify tumor-infiltrating CD8-positive (CD8 EXPERIMENTAL

designWe generated a peripheral blood mononuclear cell (PBMC) humanized immune system (HIS) mouse model and quantified the absolute number of CD8

resultsNontumor-bearing NOG mice injected with human PBMCs showed prominent [

conclusionsHuman CD8

Indexed as

AnimalsBrain NeoplasmsCD8 AntigensCD8-Positive T-LymphocytesCopper RadioisotopesFemaleGlioblastomaHeterocyclic Compounds, 1-RingHumansIsotope LabelingLymphocytes, Tumor-InfiltratingMicePositron-Emission TomographyRadiopharmaceuticals1,4,7-triazacyclononane-N,N',N''-triacetic acidCD8 AntigensCopper-64Copper RadioisotopesHeterocyclic Compounds, 1-RingRadiopharmaceuticals

Identifiers

PMID33495310
PMCPMC8026513
OpenAlexW3125550917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.