Evidence map›Paper›PMID 33495268›Full record

ArticleGut2021

Long-term effectiveness of faecal immunochemical test screening for proximal and distal colorectal cancers.

Han-Mo Chiu, Grace Hsiao-Hsuan Jen, Ying-Wei Wang, Jean Ching-Yuan Fann, Chen-Yang Hsu, Ya-Chung Jeng, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Sam Li-Sheng Chen, Wen-Feng Hsu and 5 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05740267 (Natural Orifice Specimen Extraction Surgery for Colorectal Cancer), which is not on this map. Cited by 49 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 5 pooled it
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05740267 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Natural Orifice Specimen Extraction Surgery for Colorectal Cancer (NOSE for CRC)

TypeinterventionalSponsorChang Gung Memorial HospitalRan2023 to 2025Enrolled318ConditionsColorectal CancerArmsNatural Orifice Specimen Extraction
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Guideline
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Combating Post-colonoscopy Colorectal Cancer: Insight from the Trials and Cohort Studies.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Han-Mo ChiuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0003-2786-8056
Grace Hsiao-Hsuan JenInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Ying-Wei WangHealth Promotion Administration, Ministry of Health and Welfare, Taipei, Taiwan.
Jean Ching-Yuan FannDepartment of Health Industry Management, School of Healthcare Management, Kainan University, Taoyuan, Taiwan.
Chen-Yang HsuInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Ya-Chung JengSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Amy Ming-Fang YenSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0002-0628-8768
Sherry Yueh-Hsia ChiuDepartment of Health Care Management, College of Management, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0002-7207-7088
Sam Li-Sheng ChenSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0002-5799-6705
Wen-Feng HsuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yi-Chia LeeDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0002-8160-1216
Ming-Shiang WuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0001-5325-3974
Chien-Yuan WuHealth Promotion Administration, Ministry of Health and Welfare, Taipei, Taiwan.
Yann-Yuh JouHealth Promotion Administration, Ministry of Health and Welfare, Taipei, Taiwan.
Tony Hsiu-Hsi ChenInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan chenlin@ntu.edu.tw.ORCID 0000-0002-5799-6705
National Taiwan University · TWMinistry of Health and Welfare · TWNational Taiwan University Hospital · TWTaipei Medical University · TWChang Gung University · TWKainan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo measure the effects of faecal immunochemical test (FIT) for colorectal cancer (CRC) screening on overall and site-specific long-term effectiveness of population-based organised service screening.

designA prospective cohort study of Taiwanese nationwide biennial FIT screening was performed. A total of 5 417 699 eligible subjects were invited to attend screening from 2004 through 2009 and were followed up until 2014. We estimated the adjusted relative rates (aRRs) on the effectiveness of reducing advanced-stage CRC (stage II+) and CRC death by Bayesian Poisson regression models with the full adjustment for a cascade of self-selection factors (including the screening rate and the colonoscopy rate) and the completeness of colonoscopy together with demographic features.

resultsFIT screening (exposed vs unexposed) reduced the incidence of advanced-stage CRC (48.4 vs 75.7 per 100 000) and mortality (20.3 vs 41.3 per 100 000). Statistically significant reductions of both incidence of advanced-stage CRCs (aRR=0.66, 95% CI 0.63 to 0.70) and deaths from CRC (aRR=0.60, 95% CI 0.57 to 0.64) were noted. FIT screening was more effective in reducing distal advanced-stage CRCs (aRR=0.61, 95% CI 0.58 to 0.64) and CRC mortality (aRR=0.56, 95% CI 0.53 to 0.69) than proximal advanced CRCs (aRR=0.84, 95% CI 0.77 to 0.92) and CRC mortality (aRR=0.72, 95% CI 0.66 to 0.80).

conclusionA large-scale population-based biennial FIT screening demonstrates 34% significant reduction of advanced-stage CRCs and 40% reduction of death from CRC with larger long-term effectiveness in the distal colon than the proximal colon. Our findings provide a strong and consistent evidence-based policy for supporting a sustainable population-based FIT organised service screening worldwide. The disparity of site-specific long-term effectiveness also provides an insight into the remedy for lower effectiveness of FIT screening in the proximal colon.

Indexed as

AgedBayes TheoremColorectal NeoplasmsEarly Detection of CancerFecesFemaleHumansIncidenceMaleMass ScreeningMiddle AgedNeoplasm StagingProspective StudiesTaiwancancer epidemiologycancer preventioncolorectal cancer screening

Identifiers

PMID33495268
PMCPMC8588305
OpenAlexW3122038952

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.