Evidence map›Paper›PMID 33495243›Full record

ArticleeNeuro

Neuregulin-4 Is Required for Maintaining Soma Size of Pyramidal Neurons in the Motor Cortex.

Blanca Paramo, Sven O Bachmann, Stéphane J Baudouin, Isabel Martinez-Garay, Alun M Davies

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Suite3D: Volumetric cell detection for two-photon microscopy.bioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Blanca ParamoSchool of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales paramob@cardiff.ac.uk.
Sven O BachmannSchool of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales.
Stéphane J BaudouinSchool of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales.ORCID 0000-0001-6902-6071
Isabel Martinez-GaraySchool of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales.
Alun M Davies
Cardiff University · GB

Funding

Wellcome TrustWellcome Trust 103852
6 · The paper itself

Abstract

The regulation of neuronal soma size is essential for appropriate brain circuit function and its dysregulation is associated with several neurodevelopmental disorders. A defect in the dendritic growth and elaboration of motor neocortical pyramidal neurons in neonates lacking neuregulin-4 (NRG4) has previously been reported. In this study, we investigated whether the loss of NRG4 causes further morphologic defects that are specific to these neurons. We analyzed the soma size of pyramidal neurons of layer (L)2/3 and L5 of the motor cortex and a subpopulation of multipolar interneurons in this neocortical region in

Indexed as

Motor CortexAnimalsMiceMice, KnockoutNeuregulinsNeuronsPyramidal Cellsneuregulin-4Neuregulinscortical developmentneuregulin-4neuronal soma sizepyramidal neurons

Identifiers

PMID33495243
PMCPMC8114872
OpenAlexW3124295261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.