Evidence map›Paper›PMID 33495242›Full record

ArticleeNeuro

The Neural Representation of Force across Grasp Types in Motor Cortex of Humans with Tetraplegia.

Anisha Rastogi, Francis R Willett, Jessica Abreu, Douglas C Crowder, Brian A Murphy, William D Memberg, Carlos E Vargas-Irwin, Jonathan P Miller, Jennifer Sweet, Benjamin L Walter and 7 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912041 (BrainGate2), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00912041 narecruitingnot on this map

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

TypeinterventionalSponsorLeigh R. Hochberg, MD, PhD.Ran2009 to 2038Enrolled27ConditionsTetraplegia, Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Brain Stem InfarctionsArmsPlacement of the BrainGate2 sensor(s) into the motor-related cortex
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Distinct Neural Modes Carry Information About Attempted Grasp Timing and Force in the Sensorimotor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Anisha RastogiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0002-8290-3558
Francis R WillettDepartment of Neurosurgery, Stanford University, Stanford, CA 94035.
Jessica AbreuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Douglas C CrowderDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Brian A MurphyDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
William D MembergDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Carlos E Vargas-IrwinDepartment of Neuroscience, Brown University, Providence, RI 02912.
Jonathan P MillerLouis Stokes Cleveland Department of VA Medical Center, Cleveland, OH 44106.
Jennifer SweetDepartment of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Benjamin L WalterLouis Stokes Cleveland Department of VA Medical Center, Cleveland, OH 44106.
Paymon G RezaiiDepartment of Neurosurgery, Stanford University, Stanford, CA 94035.
Sergey D StaviskyDepartment of Neurosurgery, Stanford University, Stanford, CA 94035.ORCID 0000-0002-5238-0573
Leigh R HochbergRobert J. and Nancy D. Carney Institute for Brain Sciences, Brown University, Providence, RI 02912.ORCID 0000-0003-0261-2273
Krishna V ShenoyDepartment of Electrical Engineering, Stanford University, Stanford, CA 94035.ORCID 0000-0003-1534-9240
Jaimie M HendersonDepartment of Neurosurgery, Stanford University, Stanford, CA 94035.
Robert F KirschDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
A Bolu AjiboyeDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 bolu.ajiboye@case.edu.ORCID 0000-0002-9402-1165
Louis Stokes Cleveland VA Medical Center · USStanford Medicine · USUniversity Hospitals of Cleveland · USAllen Institute for Brain Science · USCase Western Reserve University · USHoward Hughes Medical Institute · USNeurosciences Institute · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Engaging new cognitive and motor signals to improve communication prosthesesR01DC014034 · NIDCD · STANFORD UNIVERSITY · PI JAIMIE M HENDERSON · 2015 to 2026
$8.2M
Restoring Communication with an Intracortical Neural Interface SystemR01DC009899 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI HOCHBERG, LEIGH R · 2009 to 2017
$7.0M
Integrated Neural Engineering and Rehabilitation Training ProgramT32EB004314 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI Jeffrey R Capadona, Robert F. Kirsch · 2004 to 2026
$6.1M
Understanding the Neural Basis of Volitional State through Continuous Recordings in HumansU01NS098968 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S · 2016 to 2018
$4.7M
High-Bandwidth Wireless Interfaces for Continuous Human Intracortical RecordingUH2NS095548 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HOCHBERG, LEIGH R, NURMIKKO, ARTO · 2015 to 2019
$3.7M
NRSA Training CoreTL1TR002549 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI HARDING, CLIFFORD V · 2018 to 2022
$2.9M
Intracortical control of FES-restored arm and hand function in people with SCIR01HD077220 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI KIRSCH, ROBERT F. · 2014 to 2017
$1.7M
Evaluating Neural Force Modulation and Force-Controlled Intracortical Brain-Computer Interface Operation in Persons with Chronic ParalysisF30HD090890 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI RASTOGI, ANISHA · 2018 to 2019
$99k
VA RR&D Center for Neurorestoration and NeurotechnologyI50RX002864 · VA · PROVIDENCE VA MEDICAL CENTER · PI BENJAMIN D GREENBERG, LEIGH R HOCHBERG · 2018 to 2026
–
Restoring High Dimensional Hand Function to Persons with Chronic High TetraplegiaI01RX002654 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI AJIBOYE, ABIDEMI BOLU · 2018 to 2022
–
BrainGate: Robust Neural Decoding for Veterans with ALSI01RX002295 · VA · PROVIDENCE VA MEDICAL CENTER · PI HOCHBERG, LEIGH R · 2017 to 2025
–
NCATS NIH HHS TL1 TR002549NIBIB NIH HHS T32 EB004314NICHD NIH HHS F30 HD090890NICHD NIH HHS R01 HD077220NIDCD NIH HHS R01 DC009899NIDCD NIH HHS R01 DC014034NIGMS NIH HHS T32 GM007250NINDS NIH HHS U01 NS098968NINDS NIH HHS UH2 NS095548RRD VA I01 RX002295RRD VA I01 RX002654RRD VA I50 RX002864
6 · The paper itself

Abstract

Intracortical brain-computer interfaces (iBCIs) have the potential to restore hand grasping and object interaction to individuals with tetraplegia. Optimal grasping and object interaction require simultaneous production of both force and grasp outputs. However, since overlapping neural populations are modulated by both parameters, grasp type could affect how well forces are decoded from motor cortex in a closed-loop force iBCI. Therefore, this work quantified the neural representation and offline decoding performance of discrete hand grasps and force levels in two human participants with tetraplegia. Participants attempted to produce three discrete forces (light, medium, hard) using up to five hand grasp configurations. A two-way Welch ANOVA was implemented on multiunit neural features to assess their modulation to

Indexed as

Motor CortexHandHand StrengthHumansQuadriplegiabrain-computer interfaceforcegraspkineticmotor cortex

Identifiers

PMID33495242
PMCPMC7920535
OpenAlexW3124832125

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.