Evidence map›Paper›PMID 33495235›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Prevailing Role of Mucosal Igs and B Cells in Teleost Skin Immune Responses to Bacterial Infection.

Xiao-Ting Zhang, Yong-Yao Yu, Hao-Yue Xu, Zhen-Yu Huang, Xia Liu, Jia-Feng Cao, Kai-Feng Meng, Zheng-Ben Wu, Guang-Kun Han, Meng-Ting Zhan and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 65 citations in OpenAlex.

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  6. Immunoglobulin M response in largemouth bass (Frontiers in immunology · 2025
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  11. Mucosal immune responses toMarine life science & technology · 2024
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  12. Distinct distribution and responses of IgMFrontiers in immunology · 2024
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  13. Monoclonal antibody generated against Nile tilapia (Fish and shellfish immunology reports · 2023
    Article
  14. Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Xiao-Ting ZhangDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.ORCID 0000-0003-2157-8381
Yong-Yao YuDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.ORCID 0000-0002-4476-0015
Hao-Yue XuDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Zhen-Yu HuangDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Xia LiuDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Jia-Feng CaoDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Kai-Feng MengDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Zheng-Ben WuDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Guang-Kun HanDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Meng-Ting ZhanDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Li-Guo DingDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Wei-Guang KongDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China.ORCID 0000-0001-7466-6348
Nan LiState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, Hubei, China.ORCID 0000-0003-2186-2921
Fumio TakizawaFaculty of Marine Science and Technology, Fukui Prefectural University, Obama, Fukui 917-0003, Japan.
J Oriol SunyerDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104; and.
Zhen XuDepartment of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China; zhenxu@mail.hzau.edu.cn.ORCID 0000-0001-6598-2058
Huazhong Agricultural University · CNChinese Academy of Sciences · CNFukui Prefectural University · JPUniversity of Pennsylvania · US

Funding

Specific Contribution of a New IG Isotype (IGT) in Teleost Fish Immune ResponsesR01GM085207 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SUNYER, J. ORIOL · 2010 to 2022
$3.8M
Fence Methods for Mixed Model Selection: Theory and ApplicationsR01GM085205 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI JIANG, JIMING, RAO, J SUNIL · 2010 to 2014
$1.4M
NIGMS NIH HHS R01 GM085205NIGMS NIH HHS R01 GM085207
6 · The paper itself

Abstract

The skin of vertebrates is the outermost organ of the body and serves as the first line of defense against external aggressions. In contrast to mammalian skin, that of teleost fish lacks keratinization and has evolved to operate as a mucosal surface containing a skin-associated lymphoid tissue (SALT). Thus far, IgT representing the prevalent Ig in SALT have only been reported upon infection with a parasite. However, very little is known about the types of B cells and Igs responding to bacterial infection in the teleost skin mucosa, as well as the inductive or effector role of the SALT in such responses. To address these questions, in this study, we analyzed the immune response of trout skin upon infection with one of the most widespread fish skin bacterial pathogens,

Indexed as

AnimalsB-LymphocytesCell ProliferationFish DiseasesFish ProteinsFlavobacteriaceae InfectionsFlavobacteriumImmunity, InnateImmunity, MucosalImmunoglobulin IsotypesImmunoglobulinsInflammationLymphoid TissueMucous MembraneOncorhynchus mykissSkinFish ProteinsImmunoglobulin IsotypesImmunoglobulinsimmunoglobulin T, teleost

Identifiers

PMID33495235
PMCPMC11152320
OpenAlexW3121289907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.