Evidence map›Paper›PMID 33495219›Full record

ArticleAntimicrobial agents and chemotherapy2021

Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin.

Shivendra G Tewari, Krithika Rajaram, Russell P Swift, Jaques Reifman, Sean T Prigge, Anders Wallqvist

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. A picomolar inhibitor of theAntimicrobial agents and chemotherapy · 2024
    Article
  3. Potent Inhibition ofACS infectious diseases · 2024
    Article
  4. Article
  5. Metabolic changes that allowFrontiers in parasitology · 2024
    Article
  6. Article
  7. Targeting theHeliyon · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Shivendra G TewariDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Maryland, USA stewari@bhsai.org sven.a.wallqvist.civ@mail.mil.ORCID 0000-0003-0310-0915
Krithika RajaramDepartment of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-4830-5471
Russell P SwiftDepartment of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-1442-9740
Jaques ReifmanDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Maryland, USA.ORCID 0000-0001-7292-2029
Sean T PriggeDepartment of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-9684-1733
Anders WallqvistDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Maryland, USA stewari@bhsai.org sven.a.wallqvist.civ@mail.mil.ORCID 0000-0002-9775-7469
Johns Hopkins University · USTelemedicine & Advanced Technology Research Center · USHenry M. Jackson Foundation · US

Funding

Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
Determinants of apicoplast maintenance in malaria parasitesR01AI125534 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Sean Taylor PRIGGE · 2016 to 2026
$3.9M
Roles of Lipoate Pathways in Plasmodium SurvivalR01AI065853 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PRIGGE, SEAN TAYLOR · 2006 to 2010
$2.0M
NIAID NIH HHS R01 AI065853NIAID NIH HHS R01 AI125534NIAID NIH HHS T32 AI007417
6 · The paper itself

Abstract

The malaria parasite

Indexed as

AntimalarialsApicoplastsFosfomycinMalaria, FalciparumHumansPlasmodium falciparumAntimalarialsFosfomycinfosmidomycinapicoplastfosmidomycingenome-scale metabolic modelmetabolic modelingmetabolomicsPlasmodium falciparumprenylationtranscriptomics

Identifiers

PMID33495219
PMCPMC8097461
OpenAlexW3124661111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.