Evidence map›Paper›PMID 33495218›Full record

ArticleAntimicrobial agents and chemotherapy2021

Induction of Native c-di-GMP Phosphodiesterases Leads to Dispersal of Pseudomonas aeruginosa Biofilms.

Jens Bo Andersen, Kasper Nørskov Kragh, Louise Dahl Hultqvist, Morten Rybtke, Martin Nilsson, Tim Holm Jakobsen, Michael Givskov, Tim Tolker-Nielsen

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. BioMed research international · 2026
    Review
  3. Review
  4. Stress adaptation underMicrobiology spectrum · 2025
    Article
  5. Article
  6. Article
  7. High efficacy treatment of murineAntimicrobial agents and chemotherapy · 2024
    Article
  8. International journal of molecular sciences · 2024
    Article
  9. Inhibition ofAntimicrobial agents and chemotherapy · 2024
    Article
  10. Review
  11. Bacterial respiratory inhibition triggers dispersal ofApplied and environmental microbiology · 2023
    Article
  12. Article
  13. The non-attached biofilm aggregate.Communications biology · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Controlling Biofilm Development Through Cyclic di-GMP Signaling.Advances in experimental medicine and biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Jens Bo AndersenCosterton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kasper Nørskov KraghCosterton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7662-9118
Louise Dahl HultqvistCosterton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Morten RybtkeCosterton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Martin NilssonCosterton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Tim Holm JakobsenCosterton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Michael GivskovCosterton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Tim Tolker-NielsenCosterton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark ttn@sund.ku.dk.ORCID 0000-0002-9751-474X
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A decade of research has shown that the molecule c-di-GMP functions as a central second messenger in many bacteria. A high level of c-di-GMP is associated with biofilm formation, whereas a low level of c-di-GMP is associated with a planktonic single-cell bacterial lifestyle. c-di-GMP is formed by diguanylate cyclases and is degraded by specific phosphodiesterases. We previously presented evidence that the ectopic expression of the

Indexed as

Escherichia coli ProteinsPseudomonas aeruginosaBacterial ProteinsBiofilmsCyclic GMPGene Expression Regulation, BacterialPhosphoric Diester HydrolasesBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPEscherichia coli ProteinsPhosphoric Diester Hydrolasesbiofilm dispersalc-di-GMPphosphodiesterasePseudomonas aeruginosa

Identifiers

PMID33495218
PMCPMC8097489
OpenAlexW3121400140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.