ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2021
Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Post-task responses following working memory and movement are driven by transient spectral bursts with similar characteristics.Human brain mapping · 2024Article
- Neural activity during inhibitory control predicts suicidal ideation with machine learning.NPP - digital psychiatry and neuroscience · 2024Article
- Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Neurobiology of Psychosis and Schizophrenia 2021: Nottingham Meeting.Schizophrenia bulletin · 2022Article
- Imprecise Predictive Coding Is at the Core of Classical Schizophrenia.Frontiers in human neuroscience · 2022Article
- Spontaneous activity competes with externally evoked responses in sensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Small Words That Matter: Linguistic Style and Conceptual Disorganization in Untreated First-Episode Schizophrenia.Schizophrenia bulletin open · 2021Article
- A neuroscientist's guide to neural burst detection.Imaging neuroscience (Cambridge, Mass.)Article
- Beta bursts spatiotemporal profiles and their links to hemodynamic responses during movement and rest.Imaging neuroscience (Cambridge, Mass.)Article
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10 authors at 2 institutions in 2 countries.
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Abstract
backgroundThere is emerging evidence for abnormal beta oscillations in psychosis. Beta oscillations are likely to play a key role in the coordination of sensorimotor information that is crucial to healthy mental function. Growing evidence suggests that beta oscillations typically manifest as transient beta bursts that increase in probability following a motor response, observable as post-movement beta rebound. Evidence indicates that post-movement beta rebound is attenuated in psychosis, with greater attenuation associated with greater symptom severity and impairment. Delineating the functional role of beta bursts therefore may be key to understanding the mechanisms underlying persistent psychotic illness.
methodsWe used concurrent electroencephalography and functional magnetic resonance imaging to identify blood oxygen level-dependent correlates of beta bursts during the n-back working memory task and intervening rest periods in healthy control participants (n = 30) and patients with psychosis (n = 48).
resultsDuring both task blocks and intervening rest periods, beta bursts phasically activated regions implicated in task-relevant content while suppressing currently tonically active regions. Patients showed attenuated post-movement beta rebound that was associated with persisting disorganization symptoms as well as impairments in cognition and role function. Patients also showed greater task-related reductions in overall beta burst rate and showed greater, more extensive, beta burst-related blood oxygen level-dependent activation.
conclusionsOur evidence supports a model in which beta bursts reactivate latently maintained sensorimotor information and are dysregulated and inefficient in psychosis. We propose that abnormalities in the mechanisms by which beta bursts coordinate reactivation of contextually appropriate content can manifest as disorganization, working memory deficits, and inaccurate forward models and may underlie a core deficit associated with persisting symptoms and impairment.
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