ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2021
Obsessive-Compulsive Symptoms Among Children in the Adolescent Brain and Cognitive Development Study: Clinical, Cognitive, and Brain Connectivity Correlates.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- White matter abnormalities in paediatric obsessive-compulsive disorder: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2023Pooled it
- Functional connectivity alterations between default mode network and occipital cortex in patients with obsessive-compulsive disorder (OCD).NeuroImage. Clinical · 2022Pooled it
- Changes in Brain Network Connections After Exposure and Response Prevention Therapy for Obsessive-Compulsive Disorder in Adolescents and Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Trial
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- Friends, family, and community influences on adolescent development: A review of impactful findings from the ABCD study®.Developmental cognitive neuroscience · 2026Article
- Household cannabis cessation and adolescent mental health outcomes in a prospective cohort study.BMC medicine · 2026Article
- Demographic, genetic, neuroimaging, and behavioral correlates of short social responsiveness scale in a large pediatric cohort.Translational psychiatry · 2025Article
- Longitudinal Sex-at-Birth and Age Analyses of Cortical Structure in the ABCD Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Structural Brain Correlates of Anxiety During Development.Current topics in behavioral neurosciences · 2025Review
- Article
- Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD study.Brain research bulletin · 2024Article
- Deficiency in Self-Control: Unraveling Psychological and Behavioral Risk Factors for Obsessive-Compulsive Symptoms in College Students.Psychology research and behavior management · 2024Article
- Comparing the stability and reproducibility of brain-behavior relationships found using canonical correlation analysis and partial least squares within the ABCD sample.Network neuroscience (Cambridge, Mass.) · 2024Article
- Resting-state brain networks alterations in adolescents with Internet Gaming Disorder associate with cognitive control impairments.Frontiers in psychiatry · 2024Article
- Dissecting Psychiatric Heterogeneity and Comorbidity with Core Region-Based Machine Learning.Neuroscience bulletin · 2023Review
- Error-related brain activity associated with obsessive-compulsive symptoms in youth.Brain and behavior · 2023Article
- White matter microstructure shows sex differences in late childhood: Evidence from 6797 children.Human brain mapping · 2023Article
- Obsessive-compulsive symptoms and resting-state functional characteristics in pre-adolescent children from the general population.Brain imaging and behavior · 2022Article
- Neurogenetics of Dynamic Connectivity Patterns Associated With Obsessive-Compulsive Symptoms in Healthy Children.Biological psychiatry global open science · 2022Article
- Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth.Translational psychiatry · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChildhood obsessive-compulsive symptoms (OCSs) are common and can be an early risk marker for obsessive-compulsive disorder. The Adolescent Brain and Cognitive Development (ABCD) Study provides a unique opportunity to characterize OCSs in a large normative sample of school-age children and to explore corticostriatal and task-control circuits implicated in pediatric obsessive-compulsive disorder.
methodsThe ABCD Study acquired data from 9- and 10-year-olds (N = 11,876). Linear mixed-effects models probed associations between OCSs (Child Behavior Checklist) and cognition (NIH Toolbox), brain structure (subcortical volume, cortical thickness), white matter (diffusion tensor imaging), and resting-state functional connectivity.
resultsOCS scores showed good psychometric properties and high prevalence, and they were related to familial/parental factors, including family conflict. Higher OCS scores related to better cognitive performance (β = .06, t
conclusionsOCSs are common and may persist throughout childhood. Corticostriatal connectivity and attention network connectivity are likely mechanisms in the subclinical-to-clinical spectrum of OCSs. Understanding correlates and mechanisms of OCSs may elucidate their role in childhood psychiatric risk and suggest potential utility of neuroimaging, e.g., dorsal attention-default mode connectivity, for identifying children at increased risk for obsessive-compulsive disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.