ArticleeLife2021
A dietary sterol trade-off determines lifespan responses to dietary restriction in
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Article
- Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mating-dependent lifespan cost of sterol depletion in maleProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Effect of Aerobic Exercise and a Diet Supplementation with Linoleic Acid on Metabolic Parameters inBiology · 2026Article
- Pleiotropic Cholesterol Signaling inMetabolites · 2026Review
- Short lifespan under dietary cholesterol depletion is associated with gut dysfunction in Drosophila melanogaster females.npj aging · 2026Article
- Sex-specific effects of cereal-based diets on longevity and healthspan in Drosophila melanogaster.Biogerontology · 2026Article
- Systematic analysis of nutrient-microbiome interactions and their effects on host phenotypes inmBio · 2025Article
- Microbiota-host crosstalk: the role of short-term dietary restriction in neurological and metabolic dysregulation.NPJ biofilms and microbiomes · 2025Article
- Variation in the resource environment affects patterns of seasonal adaptation at phenotypic and genomic levels inEvolution letters · 2025Article
- Beta-Hydroxybutyrate but not NMN supplementation mimics caloric restriction reducing early mortality in Daphnia.Biogerontology · 2025Article
- Spermidine supplementation and protein restriction protect from organismal and brain aging independently.Aging · 2025Article
- Reproductive-Triggered Sterol Competition Exacerbates Age-Related Intestinal Barrier Damage in Drosophila Females.Aging cell · 2025Article
- Dietary Zinc Limitation Dictates Lifespan and Reproduction Trade-Offs of Drosophila Mothers.Aging cell · 2025Article
- Macronutrient-Based Predictive Modelling of Bioconversion Efficiency in Black Soldier Fly Larvae (Insects · 2025Article
- The evolution of ageing: classic theories and emerging ideas.Biogerontology · 2024Review
- High-quality dietary protein (essential amino acids matched to reproductive needs) partially breaks the lifespan and reproduction trade-off in lubber grasshoppers.Biogerontology · 2024Article
- Extended lifespan in female Drosophila melanogaster through late-life calorie restriction.GeroScience · 2024Article
- Pharmacology of Aging:Aging biology · 2024Article
- Context-dependent impact of the dietary non-essential amino acid tyrosine onScience advances · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diet plays a significant role in maintaining lifelong health. In particular, lowering the dietary protein: carbohydrate ratio can improve lifespan. This has been interpreted as a direct effect of these macronutrients on physiology. Using
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.