ArticleeLife2021
Deleting
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Movement disorders in patients with Rett syndrome: A systematic review of evidence and associated clinical considerations.Psychiatry and clinical neurosciences · 2021Pooled it
- MeCP2 is Necessary in Cerebellar Purkinje Cells for Precise Network Dynamics During Associative Motor Learning.bioRxiv : the preprint server for biology · 2026Article
- Dysregulated Cholesterol Clearance via CYP46A1 Contributes to Cerebellar Sterol Imbalance inInternational journal of molecular sciences · 2026Article
- Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity.Molecular autism · 2026Article
- MeCP2 regulates telencephalic development in human cerebral organoids.Cell reports · 2025Article
- Shank3 establishes AMPA receptor subunit composition at cerebellar mossy fiber-granule cell synapses and is associated with altered regional microglial morphology.Neurobiology of disease · 2025Article
- Zebrafish mecp2 null-mutation increases anxiety and cortisol levels but no change in adult social preference and larval chemically-induced hyperlocomotion.BMC neuroscience · 2025Article
- Molecular Insights into Neurological Regression with a Focus on Rett Syndrome-A Narrative Review.International journal of molecular sciences · 2025Review
- Rett syndrome.Nature reviews. Disease primers · 2024Review
- Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice.Cerebellum (London, England) · 2024Review
- Behavioral regression in shank3Research square · 2024Article
- Modulation of Brain Cholesterol Metabolism through CYP46A1 Overexpression for Rett Syndrome.Pharmaceutics · 2024Article
- The Efficacy of a Human-Ready miniGenes · 2023Article
- Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome.Journal of translational medicine · 2023Article
- Advanced genetic therapies for the treatment of Rett syndrome: state of the art and future perspectives.Frontiers in neuroscience · 2023Review
- Deficits in cerebellum-dependent learning and cerebellar morphology in male and female BTBR autism model mice.NeuroSci · 2022Article
- MeCP2 loss-of-function dysregulates microRNAs regionally and disrupts excitatory/inhibitory synaptic transmission balance.Hippocampus · 2022Article
- The Cerebellar Involvement in Autism Spectrum Disorders: From the Social Brain to Mouse Models.International journal of molecular sciences · 2022Review
- Rett Syndrome andNeuropsychiatric disease and treatment · 2022Review
- P-sort: an open-source software for cerebellar neurophysiology.Journal of neurophysiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Nathan P AchillyJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.ORCID 0000-0002-0307-2662
Ling-Jie HeJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.
Olivia A KimDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Shogo OhmaeDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.ORCID 0000-0003-1726-4961
Gregory J WojaczynskiDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Tao LinJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.
Roy V SillitoeJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.ORCID 0000-0002-6177-6190
Javier F MedinaDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Huda Y ZoghbiJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.ORCID 0000-0002-0700-3349
Baylor College of Medicine · USHoward Hughes Medical Institute · US
Funding
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9MSteps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8MMOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROMER01NS057819 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ZOGHBI, HUDA Y · 2006 to 2025
$7.5MCoding and processing of error signals in inferior olivary-cerebellar networksR01MH093727 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI JAVIER F MEDINA · 2011 to 2026
$6.7MCanonical computations for motor learning by the cerebellar cortex micro-circuitR01NS112917 · NINDS · DUKE UNIVERSITY · PI LISBERGER, STEPHEN G, MEDINA, JAVIER F · 2019 to 2023
$6.4MThe impact of cerebellar tDCS in local and downstream brain circuits: how much is neuralactivity modulated in the resting state and during sensorimotor processing?RF1MH114269 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI MEDINA, JAVIER F · 2017 to 2017
$2.0MCEREBELLAR FUNCTION IN TREMORR01NS100874 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2017 to 2021
$1.9MSYNAPTIC ORIGINS OF CEREBELLAR DISEASER01NS089664 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2014 to 2018
$1.7MComputation of negative prediction error in the inferior olive and its role in cerebellar motor learningF31NS103427 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI KIM, OLIVIA ANN · 2017 to 2019
$134kUnderstanding the role of MeCP2 in the cerebellum and the therapeutic potential of extended training in Rett syndromeF30HD097871 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ACHILLY, NATHAN · 2019 to 2021
$130kHoward Hughes Medical InstituteNICHD NIH HHS F30 HD097871NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIH HHS F30HD09787NIH HHS F31NS103427NIH HHS R01NS112917NIMH NIH HHS R01 MH093727NIMH NIH HHS RF1 MH114269NINDS NIH HHS F31 NS103427NINDS NIH HHS R01 NS057819NINDS NIH HHS R01 NS089664NINDS NIH HHS R01 NS100874NINDS NIH HHS R01 NS112917
Abstract
Rett syndrome is a devastating childhood neurological disorder caused by mutations in
Indexed as
Gene DeletionLearningAnimalsCerebellumDisease Models, AnimalHumansMaleMethyl-CpG-Binding Protein 2MiceMice, KnockoutMotor ActivityNeuronsRett SyndromeTime FactorsMecp2 protein, mouseMethyl-CpG-Binding Protein 2cerebellumMeCP2motor learningmouseneuroscienceRett syndrome
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.