Evidence map›Paper›PMID 33494854›Full record

ArticleDevelopment and psychopathology2022

Epigenetic profiling of social communication trajectories and co-occurring mental health problems: a prospective, methylome-wide association study.

Jolien Rijlaarsdam, Charlotte A M Cecil, Caroline L Relton, Edward D Barker

Open access · hybridAbstract read
In one paragraph

Article in Development and psychopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.Journal of child psychology and psychiatry, and allied disciplines · 2024
    Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Jolien RijlaarsdamDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0002-2360-518X
Charlotte A M CecilDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.
Caroline L ReltonMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Edward D BarkerDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Erasmus MC · NLKing's College London · GBUniversity of Bristol · GB

Funding

Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental RisksR01HD068437 · NICHD · KING'S COLLEGE LONDON · PI BARKER, EDWARD D., MILL, JONATHAN · 2012 to 2014
$1.1M
Biotechnology and Biological Sciences Research Council BB/I025263/1Biotechnology and Biological Sciences Research Council BBI025751/1Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/5Medical Research Council MC UU 12013/2Medical Research Council MC UU 12013/8NICHD NIH HHS R01 HD068437Wellcome TrustWellcome Trust 102215/2/13/2
6 · The paper itself

Abstract

While previous studies suggest that both genetic and environmental factors play an important role in the development of autism-related traits, little is known about potential biological mechanisms underlying these associations. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined prospective associations between DNA methylation (DNAm:

Indexed as

EpigenomeMental HealthAdolescentChildCommunicationDNA MethylationEpigenesis, GeneticHumansInfant, NewbornLongitudinal StudiesALSPACautistic traitsDNA methylationlongitudinalmethylome-wide

Identifiers

PMID33494854
PMCPMC8622455
OpenAlexW3124215218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.